Topiramate is a white crystalline solid with powerful anticonvulsant
activity and is used to treat epilepsy. Drug manufacturing involves
various physical and chemical processes, which may lead to the formation
of an unexpected, or undesired, crystalline phase, in a phenomenon known
as polymorphism. In this paper, the behavior of topiramate crystal is
studied under pressures up to 10.8 GPa using Raman spectroscopy. Under
the conditions employed, Raman spectra from topiramate under pressure
showed no strong evidence of a phase change, although amorphization may
be considered. This may be accounted for by its crystal structure,
comprising oppositely running chains of topiramate molecules linked by
asymmetric hydrogen bonds, which pose a kinetic barrier against a
structural change. It is not yet safe to rule out the existence of
topiramate polymorphs, which could possibly be obtained under special
crystallization conditions, but not after compression, at least up to 10
GPa. Copyright (C) 2009 John Wiley & Sons, Ltd.
%0 Journal Article
%1 WOS:000276649900015
%A Jr., Diniz M Sena
%A Freire, Paulo T C
%A Filho, Josue Mendes
%A Melo, Francisco E A
%C 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
%D 2010
%I WILEY
%J JOURNAL OF RAMAN SPECTROSCOPY
%K crystals; high organic polymorphism; pressure} strain; {topiramate;
%N 3
%P 356-359
%R 10.1002/jrs.2441
%T Raman spectroscopy of topiramate under high pressure conditions
%V 41
%X Topiramate is a white crystalline solid with powerful anticonvulsant
activity and is used to treat epilepsy. Drug manufacturing involves
various physical and chemical processes, which may lead to the formation
of an unexpected, or undesired, crystalline phase, in a phenomenon known
as polymorphism. In this paper, the behavior of topiramate crystal is
studied under pressures up to 10.8 GPa using Raman spectroscopy. Under
the conditions employed, Raman spectra from topiramate under pressure
showed no strong evidence of a phase change, although amorphization may
be considered. This may be accounted for by its crystal structure,
comprising oppositely running chains of topiramate molecules linked by
asymmetric hydrogen bonds, which pose a kinetic barrier against a
structural change. It is not yet safe to rule out the existence of
topiramate polymorphs, which could possibly be obtained under special
crystallization conditions, but not after compression, at least up to 10
GPa. Copyright (C) 2009 John Wiley & Sons, Ltd.
@article{WOS:000276649900015,
abstract = {Topiramate is a white crystalline solid with powerful anticonvulsant
activity and is used to treat epilepsy. Drug manufacturing involves
various physical and chemical processes, which may lead to the formation
of an unexpected, or undesired, crystalline phase, in a phenomenon known
as polymorphism. In this paper, the behavior of topiramate crystal is
studied under pressures up to 10.8 GPa using Raman spectroscopy. Under
the conditions employed, Raman spectra from topiramate under pressure
showed no strong evidence of a phase change, although amorphization may
be considered. This may be accounted for by its crystal structure,
comprising oppositely running chains of topiramate molecules linked by
asymmetric hydrogen bonds, which pose a kinetic barrier against a
structural change. It is not yet safe to rule out the existence of
topiramate polymorphs, which could possibly be obtained under special
crystallization conditions, but not after compression, at least up to 10
GPa. Copyright (C) 2009 John Wiley & Sons, Ltd.},
added-at = {2022-05-23T20:00:14.000+0200},
address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA},
author = {Jr., Diniz M Sena and Freire, Paulo T C and Filho, Josue Mendes and Melo, Francisco E A},
biburl = {https://www.bibsonomy.org/bibtex/25f9415c2482326287c1b614b2fcf29c4/ppgfis_ufc_br},
doi = {10.1002/jrs.2441},
interhash = {3134979515e7195afaf560834be3335d},
intrahash = {5f9415c2482326287c1b614b2fcf29c4},
issn = {0377-0486},
journal = {JOURNAL OF RAMAN SPECTROSCOPY},
keywords = {crystals; high organic polymorphism; pressure} strain; {topiramate;},
number = 3,
pages = {356-359},
publisher = {WILEY},
pubstate = {published},
timestamp = {2022-05-23T20:00:14.000+0200},
title = {Raman spectroscopy of topiramate under high pressure conditions},
tppubtype = {article},
volume = 41,
year = 2010
}