%0 Journal Article %1 Hartmann.2011 %A Hartmann, Christian %A Hentschel, Bettina %A Tatagiba, Marcos %A Schramm, Johannes %A Schnell, Oliver %A Seidel, Clemens %A Stein, Robert %A Reifenberger, Guido %A Pietsch, Torsten %A Deimling, Andreas von %A Loeffler, Markus %A Weller, Michael %D 2011 %J Clinical cancer research : an official journal of the American Association for Cancer Research %K Adolescent Adult Aged DNA_Methylation/genetics Disease_Progression Female Glioma/diagnosis/genetics/mortality/pathology Humans Male Middle_Aged Mutation/genetics Prognosis Survival_Analysis Tumor_Markers,_Biological/genetics Young_Adult %N 13 %P 4588–4599 %T Molecular markers in low-grade gliomas: predictive or prognostic? %V 17 %X PURPOSE\r\nTo investigate whether TP53 mutation, 1p/19q codeletions, O(6)-methylguanylmethyltransferase (MGMT) promoter methylation, and isocitrate dehydrogenase 1 (IDH1) mutation predict natural course of disease or response to radiotherapy or chemotherapy or both in low-grade glioma patients.\r\nEXPERIMENTAL DESIGN\r\nCohort A consisted of 89 patients with diffuse astrocytoma World Health Organization (WHO) grade II (n = 40), oligoastrocytoma (n = 23), or oligodendroglioma (n = 26) who did not receive radiotherapy or chemotherapy after first operation and were monitored until progression progressive disease (PD); n = 59 and beyond or until the end of follow-up (n = 30). Cohort B consisted of 50 patients with WHO grade II gliomas who received radiotherapy or chemotherapy at diagnosis. Tumors were analyzed for TP53 mutations, 1p/19q codeletions, MGMT promoter methylation, and IDH1 mutations.\r\nRESULTS\r\nMedian progression-free survival (PFS) in cohort A was 4.1 years (95\% CI: 3.1-5.1). No molecular marker was prognostic for PFS after surgery alone, using multivariate adjustment for histology, age, and extent of resection. IDH1 mutations were associated with prolonged survival from the diagnosis of PD in oligoastrocytomas (OA II)/oligodendrogliomas (O II) and with overall survival (OS) in all tumors. 1p/19q codeletion and IDH1 mutation were prognostic for PFS and OS in cohort B.\r\nCONCLUSIONS\r\nNone of the parameters are sensitive prognostic biomarkers in WHO grade II glioma patients who do not receive radiotherapy or chemotherapy after surgery. Limitations of this study include the selection of patients with favorable outcome, the nonrandomized allocation of treatment, and the insufficient sample size to distinguish between effects of radiotherapy versus chemotherapy. Regardless of histology, IDH1 mutation status is the strongest prognostic marker for OS.

@article{Hartmann.2011, abstract = {PURPOSE\r\nTo investigate whether TP53 mutation, 1p/19q codeletions, O(6)-methylguanylmethyltransferase (MGMT) promoter methylation, and isocitrate dehydrogenase 1 (IDH1) mutation predict natural course of disease or response to radiotherapy or chemotherapy or both in low-grade glioma patients.\r\nEXPERIMENTAL DESIGN\r\nCohort A consisted of 89 patients with diffuse astrocytoma World Health Organization (WHO) grade II (n = 40), oligoastrocytoma (n = 23), or oligodendroglioma (n = 26) who did not receive radiotherapy or chemotherapy after first operation and were monitored until progression [progressive disease (PD); n = 59] and beyond or until the end of follow-up (n = 30). Cohort B consisted of 50 patients with WHO grade II gliomas who received radiotherapy or chemotherapy at diagnosis. Tumors were analyzed for TP53 mutations, 1p/19q codeletions, MGMT promoter methylation, and IDH1 mutations.\r\nRESULTS\r\nMedian progression-free survival (PFS) in cohort A was 4.1 years (95\% CI: 3.1-5.1). No molecular marker was prognostic for PFS after surgery alone, using multivariate adjustment for histology, age, and extent of resection. IDH1 mutations were associated with prolonged survival from the diagnosis of PD in oligoastrocytomas (OA II)/oligodendrogliomas (O II) and with overall survival (OS) in all tumors. 1p/19q codeletion and IDH1 mutation were prognostic for PFS and OS in cohort B.\r\nCONCLUSIONS\r\nNone of the parameters are sensitive prognostic biomarkers in WHO grade II glioma patients who do not receive radiotherapy or chemotherapy after surgery. Limitations of this study include the selection of patients with favorable outcome, the nonrandomized allocation of treatment, and the insufficient sample size to distinguish between effects of radiotherapy versus chemotherapy. Regardless of histology, IDH1 mutation status is the strongest prognostic marker for OS.}, added-at = {2014-10-14T15:28:00.000+0200}, author = {Hartmann, Christian and Hentschel, Bettina and Tatagiba, Marcos and Schramm, Johannes and Schnell, Oliver and Seidel, Clemens and Stein, Robert and Reifenberger, Guido and Pietsch, Torsten and Deimling, Andreas von and Loeffler, Markus and Weller, Michael}, biburl = {https://www.bibsonomy.org/bibtex/2655d38f5c713d4ef8e68b808bf80deef/drtester}, interhash = {ac8205e864a7499d098ab11ad990544b}, intrahash = {655d38f5c713d4ef8e68b808bf80deef}, journal = {Clinical cancer research : an official journal of the American Association for Cancer Research}, keywords = {Adolescent Adult Aged DNA_Methylation/genetics Disease_Progression Female Glioma/diagnosis/genetics/mortality/pathology Humans Male Middle_Aged Mutation/genetics Prognosis Survival_Analysis Tumor_Markers,_Biological/genetics Young_Adult}, number = 13, pages = {4588–4599}, timestamp = {2014-10-14T15:28:00.000+0200}, title = {Molecular markers in low-grade gliomas: predictive or prognostic?}, volume = 17, year = 2011 }