Unsupervised consensus cluster analysis of 18F-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma
Timely detection of pseudoprogression (PSP) is crucial for the management of patients with high-grade glioma (HGG) but remains difficult. Textural features of O-(2-18Ffluoroethyl)-L-tyrosine positron emission tomography (FET-PET) mirror tumor uptake heterogeneity; some of them may be associated with tumor progression.Fourteen patients with HGG and suspected of PSP underwent FET-PET imaging. A set of 19 conventional and textural FET-PET features were evaluated and subjected to unsupervised consensus clustering. The final diagnosis of true progression vs. PSP was based on follow-up MRI using RANO criteria.Three robust clusters have been identified based on 10 predominantly textural FET-PET features. None of the patients with PSP fell into cluster 2, which was associated with high values for textural FET-PET markers of uptake heterogeneity. Three out of 4 patients with PSP were assigned to cluster 3 that was largely associated with low values of textural FET-PET features. By comparison, tumor-to-normal brain ratio (TNRmax) at the optimal cutoff 2.1 was less predictive of PSP (negative predictive value 57% for detecting true progression, p=0.07 vs. 75% with cluster 3, p=0.04).Clustering based on textural O-(2-18Ffluoroethyl)-L-tyrosine PET features may provide valuable information in assessing the elusive phenomenon of pseudoprogression.
Description
Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis... - PubMed - NCBI
%0 Journal Article
%1 Kebir:2017:Oncotarget:28030820
%A Kebir, S
%A Khurshid, Z
%A Gaertner, F C
%A Essler, M
%A Hattingen, E
%A Fimmers, R
%A Scheffler, B
%A Herrlinger, U
%A Bundschuh, R A
%A Glas, M
%D 2017
%J Oncotarget
%K cancer-research glioma martin_glas
%N 5
%P 8294-8304
%R 10.18632/oncotarget.14166
%T Unsupervised consensus cluster analysis of 18F-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma
%U https://www.ncbi.nlm.nih.gov/pubmed/28030820
%V 8
%X Timely detection of pseudoprogression (PSP) is crucial for the management of patients with high-grade glioma (HGG) but remains difficult. Textural features of O-(2-18Ffluoroethyl)-L-tyrosine positron emission tomography (FET-PET) mirror tumor uptake heterogeneity; some of them may be associated with tumor progression.Fourteen patients with HGG and suspected of PSP underwent FET-PET imaging. A set of 19 conventional and textural FET-PET features were evaluated and subjected to unsupervised consensus clustering. The final diagnosis of true progression vs. PSP was based on follow-up MRI using RANO criteria.Three robust clusters have been identified based on 10 predominantly textural FET-PET features. None of the patients with PSP fell into cluster 2, which was associated with high values for textural FET-PET markers of uptake heterogeneity. Three out of 4 patients with PSP were assigned to cluster 3 that was largely associated with low values of textural FET-PET features. By comparison, tumor-to-normal brain ratio (TNRmax) at the optimal cutoff 2.1 was less predictive of PSP (negative predictive value 57% for detecting true progression, p=0.07 vs. 75% with cluster 3, p=0.04).Clustering based on textural O-(2-18Ffluoroethyl)-L-tyrosine PET features may provide valuable information in assessing the elusive phenomenon of pseudoprogression.
@article{Kebir:2017:Oncotarget:28030820,
abstract = {Timely detection of pseudoprogression (PSP) is crucial for the management of patients with high-grade glioma (HGG) but remains difficult. Textural features of O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography (FET-PET) mirror tumor uptake heterogeneity; some of them may be associated with tumor progression.Fourteen patients with HGG and suspected of PSP underwent FET-PET imaging. A set of 19 conventional and textural FET-PET features were evaluated and subjected to unsupervised consensus clustering. The final diagnosis of true progression vs. PSP was based on follow-up MRI using RANO criteria.Three robust clusters have been identified based on 10 predominantly textural FET-PET features. None of the patients with PSP fell into cluster 2, which was associated with high values for textural FET-PET markers of uptake heterogeneity. Three out of 4 patients with PSP were assigned to cluster 3 that was largely associated with low values of textural FET-PET features. By comparison, tumor-to-normal brain ratio (TNRmax) at the optimal cutoff 2.1 was less predictive of PSP (negative predictive value 57% for detecting true progression, p=0.07 vs. 75% with cluster 3, p=0.04).Clustering based on textural O-(2-[18F]fluoroethyl)-L-tyrosine PET features may provide valuable information in assessing the elusive phenomenon of pseudoprogression.},
added-at = {2017-05-26T08:26:44.000+0200},
author = {Kebir, S and Khurshid, Z and Gaertner, F C and Essler, M and Hattingen, E and Fimmers, R and Scheffler, B and Herrlinger, U and Bundschuh, R A and Glas, M},
biburl = {https://www.bibsonomy.org/bibtex/26c743fb9eb099f360c46c5c2e5953879/marcsaric},
description = {Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis... - PubMed - NCBI},
doi = {10.18632/oncotarget.14166},
interhash = {0df15a537a30fd4dcfa26e63a135ff22},
intrahash = {6c743fb9eb099f360c46c5c2e5953879},
journal = {Oncotarget},
keywords = {cancer-research glioma martin_glas},
month = jan,
number = 5,
pages = {8294-8304},
pmid = {28030820},
timestamp = {2017-05-26T08:26:44.000+0200},
title = {Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma},
url = {https://www.ncbi.nlm.nih.gov/pubmed/28030820},
volume = 8,
year = 2017
}