%0 Generic %1 durand2013reducing %A Durand, Eric Y. %A Eriksson, Nicholas %A McLean, Cory Y. %D 2013 %K IBD false_positives methods pedigrees %T Reducing pervasive false positive identical-by-descent segments detected by large-scale pedigree analysis %U http://arxiv.org/abs/1311.1120 %X Analysis of genomic segments shared identical-by-descent (IBD) between individuals is fundamental to many genetic applications, but IBD detection accuracy in non-simulated data is largely unknown. Using 25,432 genotyped European individuals, and exploiting known familial relationships in 2,952 father-mother-child trios contained therein, we identify a false positive rate over 67% for short (2-4 centiMorgan) segments. We introduce a novel, computationally-efficient, haplotype-based metric that enables accurate IBD detection on population-scale datasets.

@misc{durand2013reducing, abstract = {Analysis of genomic segments shared identical-by-descent (IBD) between individuals is fundamental to many genetic applications, but IBD detection accuracy in non-simulated data is largely unknown. Using 25,432 genotyped European individuals, and exploiting known familial relationships in 2,952 father-mother-child trios contained therein, we identify a false positive rate over 67% for short (2-4 centiMorgan) segments. We introduce a novel, computationally-efficient, haplotype-based metric that enables accurate IBD detection on population-scale datasets.}, added-at = {2013-11-16T22:51:08.000+0100}, author = {Durand, Eric Y. and Eriksson, Nicholas and McLean, Cory Y.}, biburl = {https://www.bibsonomy.org/bibtex/26dc00ebeadf2b0c402342b28773a88e1/peter.ralph}, interhash = {69dfda66ad5ba4b7955ea4ffe1f43a5a}, intrahash = {6dc00ebeadf2b0c402342b28773a88e1}, keywords = {IBD false_positives methods pedigrees}, note = {cite arxiv:1311.1120}, timestamp = {2015-01-20T22:35:53.000+0100}, title = {Reducing pervasive false positive identical-by-descent segments detected by large-scale pedigree analysis}, url = {http://arxiv.org/abs/1311.1120}, year = 2013 }