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Status of infants at birth and risk for adverse neonatal events and long-term sequelae: a study in low birth weight infants.

, , , , , , and . Am J Obstet Gynecol, 157 (3): 676--679 (September 1987)

Abstract

We evaluated the relationship of infant status at birth to neonatal morbidity and long-term development in 246 low birth weight infants (600 to 1750 gm). Nineteen percent of infants had 1-minute Apgar scores of less than or equal to 3, and 8\% had an umbilical artery pH of less than or equal to 7.2. Acidosis was associated with an increased risk of grade 3 to 4 intracranial hemorrhage (odds ratio = 3.3). Low 1-minute Apgar score was associated with an increased risk of death (odds ratio = 4.8). Grade 3 to 4 intracranial hemorrhage was a strong risk factor for cerebral palsy among survivors (odds ratio = 16.1), as was low 1-minute Apgar score (odds ratio = 2.9). Only 15\% of cases of cerebral palsy in this study were associated with acidosis at birth.

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