Murine models for the study of congestive heart failure: Implications
for understanding molecular mechanisms and for drug discovery.
J. Pharmacol. Toxicol. Methods, 50 (3):
163--174 (2004)DOI: 10.1016/j.vascn.2004.05.005
Abstract
Congestive heart failure (CHF) is a complex illness of diverse aetiology.
Despite the current multiple therapies, the prognosis for CHF patients
remains poor, and new therapeutic targets need to be identified.
With the advent of the genetic era, the mouse has become an increasingly
valuable animal species in experimental CHF research. A large number
of murine models of cardiac hypertrophy and CHF have been created
by genetic engineering. Meanwhile, traditional CHF models created
by coronary artery ligation, cardiac pressure, or volume overload
have been adapted to mice. The present review categorizes and highlights
the value of these murine models of cardiac hypertrophy and CHF.
These models, combined with sophisticated physiological measurements
of cardiac haemodynamics, are expected to yield more and valuable
information regarding the molecular mechanisms of CHF and aid in
the discovery of novel therapeutic targets.
Description
The whole bibliography file I use.