%0 Journal Article %1 Shen:2018:Mol-Carcinog:28926136 %A Shen, J %A Hodges, T R %A Song, R %A Gong, Y %A Calin, G A %A Heimberger, A B %A Zhao, H %D 2018 %J Mol Carcinog %K cancer-research glioblastoma marker paywall survival %N 1 %P 137-141 %R 10.1002/mc.22739 %T Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma %U https://www.ncbi.nlm.nih.gov/pubmed/28926136 %V 57 %X Circulating long non-coding RNAs (lncRNAs) are a new class of cancer biomarkers. However, their significance in predicting outcomes in glioblastoma patients is unclear. We measured the levels of six known oncogenic lncRNAs-CRNDE, GAS5, H19, HOTAIR, MALAT1, and TUG1 in serum samples from 106 patients with primary glioblastoma and analyzed their association with outcomes. High levels of HOTAIR were associated with decreased probability of 2-year overall survival (adjusted hazard ratio HR = 2.04; 95% confidence interval CI = 1.08-9.76), and disease-free survival (adjusted HR = 1.82; 95% CI = 1.04-6.17). High levels of GAS5 were associated with increased probability of 2-year overall survival (adjusted HR = 0.44; 95% CI = 0.18-0.99), and disease-free survival (adjusted HR = 0.46; 95% CI = 0.16-0.98). HOTAIR and GAS5 levels could serve as reciprocal prognostic predictors of survival and disease progression in patients with glioblastoma.

@article{Shen:2018:Mol-Carcinog:28926136, abstract = {Circulating long non-coding RNAs (lncRNAs) are a new class of cancer biomarkers. However, their significance in predicting outcomes in glioblastoma patients is unclear. We measured the levels of six known oncogenic lncRNAs-CRNDE, GAS5, H19, HOTAIR, MALAT1, and TUG1 in serum samples from 106 patients with primary glioblastoma and analyzed their association with outcomes. High levels of HOTAIR were associated with decreased probability of 2-year overall survival (adjusted hazard ratio [HR] = 2.04; 95% confidence interval [CI] = 1.08-9.76), and disease-free survival (adjusted HR = 1.82; 95% CI = 1.04-6.17). High levels of GAS5 were associated with increased probability of 2-year overall survival (adjusted HR = 0.44; 95% CI = 0.18-0.99), and disease-free survival (adjusted HR = 0.46; 95% CI = 0.16-0.98). HOTAIR and GAS5 levels could serve as reciprocal prognostic predictors of survival and disease progression in patients with glioblastoma.}, added-at = {2018-05-18T23:26:45.000+0200}, author = {Shen, J and Hodges, T R and Song, R and Gong, Y and Calin, G A and Heimberger, A B and Zhao, H}, biburl = {https://www.bibsonomy.org/bibtex/27d61c9b5f1382263c29166e8475014cf/marcsaric}, description = {Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma. - PubMed - NCBI}, doi = {10.1002/mc.22739}, interhash = {8cc7269d2c01668938dc27fd3a9d755f}, intrahash = {7d61c9b5f1382263c29166e8475014cf}, journal = {Mol Carcinog}, keywords = {cancer-research glioblastoma marker paywall survival}, month = jan, number = 1, pages = {137-141}, pmid = {28926136}, timestamp = {2018-05-18T23:26:45.000+0200}, title = {Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma}, url = {https://www.ncbi.nlm.nih.gov/pubmed/28926136}, volume = 57, year = 2018 }