%0 Journal Article %1 zhang2020lifethreatening %A Zhang, Qian %A Bastard, Paul %A Bolze, Alexandre %A Jouanguy, Emmanuelle %A Zhang, Shen-Ying %A Cobat, Aurélie %A Notarangelo, Luigi D. %A Su, Helen C. %A Abel, Laurent %A Casanova, Jean-Laurent %B Med %D 2020 %I Elsevier %J Med %K IFN %N 1 %P 14--20 %R 10.1016/j.medj.2020.12.001 %T Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation %U https://doi.org/10.1016/j.medj.2020.12.001 %V 1 %X The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.

@article{zhang2020lifethreatening, abstract = {The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.}, added-at = {2020-12-21T14:09:44.000+0100}, author = {Zhang, Qian and Bastard, Paul and Bolze, Alexandre and Jouanguy, Emmanuelle and Zhang, Shen-Ying and Cobat, Aurélie and Notarangelo, Luigi D. and Su, Helen C. and Abel, Laurent and Casanova, Jean-Laurent}, biburl = {https://www.bibsonomy.org/bibtex/204b48ed8145adfc6a9e59e74f4b76be4/lkanth}, booktitle = {Med}, comment = {doi: 10.1016/j.medj.2020.12.001}, description = {Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation: Med}, doi = {10.1016/j.medj.2020.12.001}, interhash = {280b2ac35c6219d860555e54732d6a13}, intrahash = {04b48ed8145adfc6a9e59e74f4b76be4}, issn = {26666359}, journal = {Med}, keywords = {IFN}, month = dec, number = 1, pages = {14--20}, publisher = {Elsevier}, timestamp = {2020-12-21T14:09:44.000+0100}, title = {Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation}, url = {https://doi.org/10.1016/j.medj.2020.12.001}, volume = 1, year = 2020 }