Four new cyclic lipopeptides, cyclo-(AFA-Ser-Gln-Asn-Tyr-Asn-Ser-Thr), named cyclodysidins A–D, were isolated from the broth culture of Streptomyces strain RV15 associated with the marine sponge Dysidea tupha. The sequences of the amino acid building blocks in the compounds and their structures were determined by 1D- and 2D-NMR techniques and CID-MS/MS experiments. The absolute configurations of all α-amino acids were determined by HPLC analysis after derivatization with Marfey’s reagent and comparison with commercially available reference samples, while those two of the β-amino fatty acids were determined by using racemic and enantiopure reference samples synthetically prepared.
%0 Journal Article
%1 abdelmohsen2012cyclodysidins
%A Abdelmohsen, Usama Ramadan
%A Zhang, Guoliang
%A Philippe, Allan
%A Schmitz, Werner
%A Pimentel-Elardo, Sheila Marie
%A Hertlein-Amslinger, Barbara
%A Hentschel, Ute
%A Bringmann, Gerhard
%D 2012
%I Elsevier
%J Tetrahedron Letters
%K myown
%N 1
%P 23-29
%T Cyclodysidins A-D, cyclic lipopeptides from the marine sponge-derived Streptomyces strain RV15
%U http://dx.doi.org/10.1016/j.tetlet.2011.10.051
%V 53
%X Four new cyclic lipopeptides, cyclo-(AFA-Ser-Gln-Asn-Tyr-Asn-Ser-Thr), named cyclodysidins A–D, were isolated from the broth culture of Streptomyces strain RV15 associated with the marine sponge Dysidea tupha. The sequences of the amino acid building blocks in the compounds and their structures were determined by 1D- and 2D-NMR techniques and CID-MS/MS experiments. The absolute configurations of all α-amino acids were determined by HPLC analysis after derivatization with Marfey’s reagent and comparison with commercially available reference samples, while those two of the β-amino fatty acids were determined by using racemic and enantiopure reference samples synthetically prepared.
@article{abdelmohsen2012cyclodysidins,
abstract = {Four new cyclic lipopeptides, cyclo-(AFA-Ser-Gln-Asn-Tyr-Asn-Ser-Thr), named cyclodysidins A–D, were isolated from the broth culture of Streptomyces strain RV15 associated with the marine sponge Dysidea tupha. The sequences of the amino acid building blocks in the compounds and their structures were determined by 1D- and 2D-NMR techniques and CID-MS/MS experiments. The absolute configurations of all α-amino acids were determined by HPLC analysis after derivatization with Marfey’s reagent and comparison with commercially available reference samples, while those two of the β-amino fatty acids were determined by using racemic and enantiopure reference samples synthetically prepared.},
added-at = {2013-02-27T11:52:11.000+0100},
author = {Abdelmohsen, Usama Ramadan and Zhang, Guoliang and Philippe, Allan and Schmitz, Werner and Pimentel-Elardo, Sheila Marie and Hertlein-Amslinger, Barbara and Hentschel, Ute and Bringmann, Gerhard},
biburl = {https://www.bibsonomy.org/bibtex/2896652345b70e18fb87abca3a3418e45/abdelmohsen},
interhash = {04eef1f7714defb1e841021b0fb1a787},
intrahash = {896652345b70e18fb87abca3a3418e45},
journal = {Tetrahedron Letters},
keywords = {myown},
number = 1,
pages = {23-29},
publisher = {Elsevier},
timestamp = {2013-02-27T12:43:01.000+0100},
title = {Cyclodysidins A-D, cyclic lipopeptides from the marine sponge-derived Streptomyces strain RV15},
url = {http://dx.doi.org/10.1016/j.tetlet.2011.10.051},
volume = 53,
year = 2012
}