We provide a systematic analysis of how odor quality,
quantity, and duration are encoded by the odorant receptor
repertoire of the Drosophila antenna. We test the receptors
with a panel of over 100 odors and find that strong responses
are sparse, with response density dependent on chemical
class. Individual receptors range along a continuum from
narrowly tuned to broadly tuned. Broadly tuned receptors are
most sensitive to structurally similar odorants. Strikingly,
inhibitory responses are widespread among receptors. The
temporal dynamics of the receptor repertoire provide a rich
representation of odor quality, quantity, and
duration. Receptors with similar odor sensitivity often map to
widely dispersed glomeruli in the antennal lobe. We construct
a multidimensional “odor
space” based on the responses of each
individual receptor and find that the positions of odors
depend on their chemical class, concentration, and molecular
complexity. The space provides a basis for predicting
behavioral responses to odors.
%0 Journal Article
%1 hallem_coding_2006
%A Hallem, Elissa A.
%A Carlson, John R.
%D 2006
%J Cell
%K drosophila olfactory
%N 1
%P 143--160
%R 10.1016/j.cell.2006.01.050
%T Coding of Odors by a Receptor Repertoire
%U http://www.sciencedirect.com/science/article/pii/S0092867406003631
%V 125
%X We provide a systematic analysis of how odor quality,
quantity, and duration are encoded by the odorant receptor
repertoire of the Drosophila antenna. We test the receptors
with a panel of over 100 odors and find that strong responses
are sparse, with response density dependent on chemical
class. Individual receptors range along a continuum from
narrowly tuned to broadly tuned. Broadly tuned receptors are
most sensitive to structurally similar odorants. Strikingly,
inhibitory responses are widespread among receptors. The
temporal dynamics of the receptor repertoire provide a rich
representation of odor quality, quantity, and
duration. Receptors with similar odor sensitivity often map to
widely dispersed glomeruli in the antennal lobe. We construct
a multidimensional “odor
space” based on the responses of each
individual receptor and find that the positions of odors
depend on their chemical class, concentration, and molecular
complexity. The space provides a basis for predicting
behavioral responses to odors.
@article{hallem_coding_2006,
abstract = { We provide a systematic analysis of how odor quality,
quantity, and duration are encoded by the odorant receptor
repertoire of the Drosophila antenna. We test the receptors
with a panel of over 100 odors and find that strong responses
are sparse, with response density dependent on chemical
class. Individual receptors range along a continuum from
narrowly tuned to broadly tuned. Broadly tuned receptors are
most sensitive to structurally similar odorants. Strikingly,
inhibitory responses are widespread among receptors. The
temporal dynamics of the receptor repertoire provide a rich
representation of odor quality, quantity, and
duration. Receptors with similar odor sensitivity often map to
widely dispersed glomeruli in the antennal lobe. We construct
a multidimensional {\textquotedblleft}odor
space{\textquotedblright} based on the responses of each
individual receptor and find that the positions of odors
depend on their chemical class, concentration, and molecular
complexity. The space provides a basis for predicting
behavioral responses to odors.},
added-at = {2014-01-19T07:01:30.000+0100},
author = {Hallem, Elissa A. and Carlson, John R.},
bdsk-url-1 = {http://www.sciencedirect.com/science/article/pii/S0092867406003631},
bdsk-url-2 = {http://dx.doi.org/10.1016/j.cell.2006.01.050},
biburl = {https://www.bibsonomy.org/bibtex/29325c5450b92db2b0cfac1e535025ce1/neurokernel},
doi = {10.1016/j.cell.2006.01.050},
interhash = {efb983a12a1d4312b24f6b5f67bec4c9},
intrahash = {9325c5450b92db2b0cfac1e535025ce1},
issn = {0092-8674},
journal = {Cell},
keywords = {drosophila olfactory},
month = apr,
number = 1,
pages = {143--160},
timestamp = {2014-01-19T07:01:30.000+0100},
title = {Coding of Odors by a Receptor Repertoire},
url = {http://www.sciencedirect.com/science/article/pii/S0092867406003631},
urldate = {2013-10-30},
volume = 125,
year = 2006
}