Mebendazole is a broad spectrum anthelminthic drug, which is widely used
in large scale deworming programmes. This active pharmaceutical
ingredient exhibits three crystal forms, namely, polymorphs A, B, and C.
Therapeutic trials suggested that the most stable form, polymorph A, is
inactive. However, the dissolution test normally used as a quality
control tool is not able to discriminate among the polymorphs of
mebendazole. In this work, the ability of the vibrational spectroscopic
techniques (mid and nearinfrared absorption and Raman scattering) for
the identification of the crystal form of this compound is evaluated. On
the basis of these observations, this methodology is applied to
determine the polymorphs of MBZ used in the formulation of the
commercial tablets available in the Brazilian and German markets.
Copyright (c) 2008 John Wiley & Sons, Ltd.
%0 Journal Article
%1 WOS:000259549700004
%A Ayala, A P
%A Siesler, H W
%A Cuffini, S L
%C 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
%D 2008
%I WILEY
%J JOURNAL OF RAMAN SPECTROSCOPY
%K Raman infrared near-infrared polymorphism; scattering; spectroscopy; spectroscopy} {mebendazole;
%N 9
%P 1150-1157
%R 10.1002/jrs.1952
%T Polymorphism incidence in commercial tablets of mebendazole: a
vibrational spectroscopy investigation
%V 39
%X Mebendazole is a broad spectrum anthelminthic drug, which is widely used
in large scale deworming programmes. This active pharmaceutical
ingredient exhibits three crystal forms, namely, polymorphs A, B, and C.
Therapeutic trials suggested that the most stable form, polymorph A, is
inactive. However, the dissolution test normally used as a quality
control tool is not able to discriminate among the polymorphs of
mebendazole. In this work, the ability of the vibrational spectroscopic
techniques (mid and nearinfrared absorption and Raman scattering) for
the identification of the crystal form of this compound is evaluated. On
the basis of these observations, this methodology is applied to
determine the polymorphs of MBZ used in the formulation of the
commercial tablets available in the Brazilian and German markets.
Copyright (c) 2008 John Wiley & Sons, Ltd.
@article{WOS:000259549700004,
abstract = {Mebendazole is a broad spectrum anthelminthic drug, which is widely used
in large scale deworming programmes. This active pharmaceutical
ingredient exhibits three crystal forms, namely, polymorphs A, B, and C.
Therapeutic trials suggested that the most stable form, polymorph A, is
inactive. However, the dissolution test normally used as a quality
control tool is not able to discriminate among the polymorphs of
mebendazole. In this work, the ability of the vibrational spectroscopic
techniques (mid and nearinfrared absorption and Raman scattering) for
the identification of the crystal form of this compound is evaluated. On
the basis of these observations, this methodology is applied to
determine the polymorphs of MBZ used in the formulation of the
commercial tablets available in the Brazilian and German markets.
Copyright (c) 2008 John Wiley & Sons, Ltd.},
added-at = {2022-05-23T20:00:14.000+0200},
address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA},
author = {Ayala, A P and Siesler, H W and Cuffini, S L},
biburl = {https://www.bibsonomy.org/bibtex/299dff274a07fa21103fda616c635b97c/ppgfis_ufc_br},
doi = {10.1002/jrs.1952},
interhash = {38f8ead2c17db5706136e34ae1bedc75},
intrahash = {99dff274a07fa21103fda616c635b97c},
issn = {0377-0486},
journal = {JOURNAL OF RAMAN SPECTROSCOPY},
keywords = {Raman infrared near-infrared polymorphism; scattering; spectroscopy; spectroscopy} {mebendazole;},
number = 9,
pages = {1150-1157},
publisher = {WILEY},
pubstate = {published},
timestamp = {2022-05-23T20:00:14.000+0200},
title = {Polymorphism incidence in commercial tablets of mebendazole: a
vibrational spectroscopy investigation},
tppubtype = {article},
volume = 39,
year = 2008
}