Bronchial mucosal folding during bronchoconstriction can be a
significant phenomenon, and a number of previous studies have provided
models which examine a number of aspects of this Important problem
Previous approaches include finite-element analyses, fluid-structure
interaction, linear elasticity models, geometrical computer
optimisation, and more. These models have focused on changes to the
elastic properties of the airways due to mucosal folding, rather than
airway narrowing, and suffer from too great a degree of computational
complexity for use in multiscale, spatially distributed models of the
lung now being developed We propose a simplified, geometrical model of
airway folding under the assumptions of fixed airway wall area, fixed
basement membrane perimeter during constriction, specified shape and
number of folds, and liquid filling of the mucosal folds, in the context
of determining effective airway radius and hence airway impedance We
show that this model generates predictions in good agreement with
existing models while being vastly simpler to solve. (C) 2010 Elsevier B
V All rights reserved
%0 Journal Article
%1 don-taw
%A Donovan, Graham M.
%A Tawhai, Merryn H.
%C PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
%D 2010
%I ELSEVIER SCIENCE BV
%J RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
%K buckling
%N 2
%P 144-150
%R 10.1016/j.resp.2010.02.011
%T A simplified model of airway narrowing due to bronchial mucosal folding
%V 171
%X Bronchial mucosal folding during bronchoconstriction can be a
significant phenomenon, and a number of previous studies have provided
models which examine a number of aspects of this Important problem
Previous approaches include finite-element analyses, fluid-structure
interaction, linear elasticity models, geometrical computer
optimisation, and more. These models have focused on changes to the
elastic properties of the airways due to mucosal folding, rather than
airway narrowing, and suffer from too great a degree of computational
complexity for use in multiscale, spatially distributed models of the
lung now being developed We propose a simplified, geometrical model of
airway folding under the assumptions of fixed airway wall area, fixed
basement membrane perimeter during constriction, specified shape and
number of folds, and liquid filling of the mucosal folds, in the context
of determining effective airway radius and hence airway impedance We
show that this model generates predictions in good agreement with
existing models while being vastly simpler to solve. (C) 2010 Elsevier B
V All rights reserved
@article{don-taw,
abstract = {{Bronchial mucosal folding during bronchoconstriction can be a
significant phenomenon, and a number of previous studies have provided
models which examine a number of aspects of this Important problem
Previous approaches include finite-element analyses, fluid-structure
interaction, linear elasticity models, geometrical computer
optimisation, and more. These models have focused on changes to the
elastic properties of the airways due to mucosal folding, rather than
airway narrowing, and suffer from too great a degree of computational
complexity for use in multiscale, spatially distributed models of the
lung now being developed We propose a simplified, geometrical model of
airway folding under the assumptions of fixed airway wall area, fixed
basement membrane perimeter during constriction, specified shape and
number of folds, and liquid filling of the mucosal folds, in the context
of determining effective airway radius and hence airway impedance We
show that this model generates predictions in good agreement with
existing models while being vastly simpler to solve. (C) 2010 Elsevier B
V All rights reserved}},
added-at = {2013-01-07T15:28:05.000+0100},
address = {{PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}},
affiliation = {{Donovan, GM (Reprint Author), Univ Auckland, Auckland Bioengn Inst, Private Bag 92019,Auckland Mail Ctr, Auckland 1142, New Zealand..
Donovan, Graham M.; Tawhai, Merryn H., Univ Auckland, Auckland Bioengn Inst, Auckland 1142, New Zealand.}},
author = {Donovan, Graham M. and Tawhai, Merryn H.},
biburl = {https://www.bibsonomy.org/bibtex/299fb1ac2d7124e5eca7776f831356964/jehiorns},
doc-delivery-number = {{609BU}},
doi = {{10.1016/j.resp.2010.02.011}},
funding-acknowledgement = {{NIH {[}NHLBI R33HL87789]}},
funding-text = {{This work was supported by NIH grant NHLBI R33HL87789.}},
interhash = {369dec46597353d62d0e831f56daa69d},
intrahash = {99fb1ac2d7124e5eca7776f831356964},
issn = {{1569-9048}},
journal = {{RESPIRATORY PHYSIOLOGY \& NEUROBIOLOGY}},
journal-iso = {{Respir. Physiol. Neuro.}},
keywords = {buckling},
keywords-plus = {{BASEMENT-MEMBRANE; ELASTIC TUBES; CLOSURE; ASTHMA; DETERMINANTS;
MECHANICS; RINGS; LUNG; FLOW}},
language = {{English}},
month = {{APR 30}},
number = {{2}},
number-of-cited-references = {{24}},
pages = {{144-150}},
publisher = {{ELSEVIER SCIENCE BV}},
research-areas = {{Physiology; Respiratory System}},
times-cited = {{2}},
timestamp = {2013-01-07T15:28:05.000+0100},
title = {{A simplified model of airway narrowing due to bronchial mucosal folding}},
type = {{Article}},
unique-id = {{ISI:000278630700012}},
volume = {{171}},
web-of-science-categories = {{Physiology; Respiratory System}},
year = {{2010}}
}