A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties.
%0 Journal Article
%1 RN125
%A Garcia-Beltran, O.
%A Mena, N.
%A Yanez, O.
%A Caballero, J.
%A Vargas, V.
%A Nunez, M.T.
%A Cassels, B.K.
%D 2013
%I 2013 Elsevier Masson SAS.
%J European Journal of Medicinal Chemistry
%K cells, chelatable chelators, chemosensor, deficiency, dqcauchile dynamics, fe2+ fe3+ fluorescent ion, iron, labile molecular probes, sensor, turn-off
%P 60-63
%R 10.1016/j.ejmech.2013.06.022
%T Design, Synthesis and Cellular Dynamics Studies in Membranes of a New Coumarin-Based "Turn-Off" Fluorescent Probe Selective for Fe2+
%U /brokenurl#<Go to ISI>://WOS:000325121800007
%V 67
%X A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties.
@article{RN125,
abstract = {A new coumarin-based 'turn-off' fluorescent probe, 7-(diethylamino)-N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-2-oxo-2H-chromene-3-carboxamide (AGD) was synthesized. This compound is highly selective for ferrous ions (Fe2+) and can reversibly detect them in aqueous medium. The probe localizes to the cell membrane in living cells, where it can detect changes in Fe2+ concentration. Molecular dynamics (MD) simulations indicate that AGD interacts with the lipid bilayer at the level of the glycerol moieties. },
added-at = {2019-12-04T03:57:35.000+0100},
author = {Garcia-Beltran, O. and Mena, N. and Yanez, O. and Caballero, J. and Vargas, V. and Nunez, M.T. and Cassels, B.K.},
biburl = {https://www.bibsonomy.org/bibtex/29fb92cdd454bfbe19ff4258f5e87ee76/dqcauchile},
doi = {10.1016/j.ejmech.2013.06.022},
interhash = {4f4b7a20e70ca5377a3fd3cd49a64925},
intrahash = {9fb92cdd454bfbe19ff4258f5e87ee76},
issn = {0223-5234},
journal = {European Journal of Medicinal Chemistry},
keywords = {cells, chelatable chelators, chemosensor, deficiency, dqcauchile dynamics, fe2+ fe3+ fluorescent ion, iron, labile molecular probes, sensor, turn-off},
pages = {60-63},
publisher = {2013 Elsevier Masson SAS.},
timestamp = {2019-12-04T03:58:17.000+0100},
title = {Design, Synthesis and Cellular Dynamics Studies in Membranes of a New Coumarin-Based "Turn-Off" Fluorescent Probe Selective for Fe2+},
type = {Journal Article},
url = {/brokenurl#<Go to ISI>://WOS:000325121800007},
volume = 67,
year = 2013
}