We study the evolution of inversions that capture locally adapted alleles when two populations are
exchanging migrants or hybridizing. By suppressing recombination between the loci, a new inversion can
spread. Neither drift nor coadaptation between the alleles (epistasis) is needed, so this local adaptation
mechanism may apply to a broader range of genetic and demographic situations than alternative hypotheses
that have been widely discussed. The mechanism can explain many features observed in
inversion systems. It will drive an inversion to high frequency if there is no countervailing force, which
could explain fixed differences observed between populations and species. An inversion can be stabilized
at an intermediate frequency if it also happens to capture one or more deleterious recessive mutations,
which could explain polymorphisms that are common in some species. This polymorphism can cycle in
frequency with the changing selective advantage of the locally favored alleles. The mechanism can
establish underdominant inversions that decrease heterokaryotype fitness by several percent if the cause
of fitness loss is structural, while if the cause is genic there is no limit to the strength of underdominance
that can result. The mechanism is expected to cause loci responsible for adaptive species-specific differences
to map to inversions, as seen in recent QTL studies. We discuss data that support the hypothesis,
review other mechanisms for inversion evolution, and suggest possible tests.
%0 Journal Article
%1 kirkpatrick2006chromosome
%A Kirkpatrick, M.
%D 2006
%I Genetics Society of America
%J Genetics
%K clines incompatibilities inversions linkage local_adaptation speciation
%N 1
%P 419--434
%R 10.1534/genetics.105.047985
%T Chromosome Inversions, Local Adaptation and Speciation
%U http://dx.doi.org/10.1534/genetics.105.047985
%V 173
%X We study the evolution of inversions that capture locally adapted alleles when two populations are
exchanging migrants or hybridizing. By suppressing recombination between the loci, a new inversion can
spread. Neither drift nor coadaptation between the alleles (epistasis) is needed, so this local adaptation
mechanism may apply to a broader range of genetic and demographic situations than alternative hypotheses
that have been widely discussed. The mechanism can explain many features observed in
inversion systems. It will drive an inversion to high frequency if there is no countervailing force, which
could explain fixed differences observed between populations and species. An inversion can be stabilized
at an intermediate frequency if it also happens to capture one or more deleterious recessive mutations,
which could explain polymorphisms that are common in some species. This polymorphism can cycle in
frequency with the changing selective advantage of the locally favored alleles. The mechanism can
establish underdominant inversions that decrease heterokaryotype fitness by several percent if the cause
of fitness loss is structural, while if the cause is genic there is no limit to the strength of underdominance
that can result. The mechanism is expected to cause loci responsible for adaptive species-specific differences
to map to inversions, as seen in recent QTL studies. We discuss data that support the hypothesis,
review other mechanisms for inversion evolution, and suggest possible tests.
@article{kirkpatrick2006chromosome,
abstract = {We study the evolution of inversions that capture locally adapted alleles when two populations are
exchanging migrants or hybridizing. By suppressing recombination between the loci, a new inversion can
spread. Neither drift nor coadaptation between the alleles (epistasis) is needed, so this local adaptation
mechanism may apply to a broader range of genetic and demographic situations than alternative hypotheses
that have been widely discussed. The mechanism can explain many features observed in
inversion systems. It will drive an inversion to high frequency if there is no countervailing force, which
could explain fixed differences observed between populations and species. An inversion can be stabilized
at an intermediate frequency if it also happens to capture one or more deleterious recessive mutations,
which could explain polymorphisms that are common in some species. This polymorphism can cycle in
frequency with the changing selective advantage of the locally favored alleles. The mechanism can
establish underdominant inversions that decrease heterokaryotype fitness by several percent if the cause
of fitness loss is structural, while if the cause is genic there is no limit to the strength of underdominance
that can result. The mechanism is expected to cause loci responsible for adaptive species-specific differences
to map to inversions, as seen in recent QTL studies. We discuss data that support the hypothesis,
review other mechanisms for inversion evolution, and suggest possible tests.},
added-at = {2016-03-08T01:55:04.000+0100},
author = {Kirkpatrick, M.},
biburl = {https://www.bibsonomy.org/bibtex/2a9c486d39c38cce18dbb164d08dbd486/peter.ralph},
doi = {10.1534/genetics.105.047985},
interhash = {74dde976d1c033486fd94653b24867e5},
intrahash = {a9c486d39c38cce18dbb164d08dbd486},
journal = {Genetics},
keywords = {clines incompatibilities inversions linkage local_adaptation speciation},
month = mar,
number = 1,
pages = {419--434},
publisher = {Genetics Society of America},
timestamp = {2016-03-08T01:55:04.000+0100},
title = {Chromosome Inversions, Local Adaptation and Speciation},
url = {http://dx.doi.org/10.1534/genetics.105.047985},
volume = 173,
year = 2006
}