%0 Journal Article %1 Qu2013 %A Qu, Yongming %D 2013 %J Clinical trials (London, England) %K imported %N 5 %P 693-5 %R 10.1177/1740774513499652 %T Statistical evaluation of surrogate markers: validity, efficiency, and sensitivity. %U http://journals.sagepub.com/doi/10.1177/1740774513499652 http://www.ncbi.nlm.nih.gov/pubmed/23988465 %V 10 %X Identification of surrogate markers for a marketed drug is important in monitoring the efficacy or safety after a patient uses the drug. In this article, we clarify the statistical definitions of the surrogate endpoint and surrogate marker and introduce the concept of the validity and efficiency of a surrogate marker. We also review some existing methods and suggest the proportion of information gain is appropriate to be used to evaluate the validity of a surrogate marker.

@article{Qu2013, abstract = {Identification of surrogate markers for a marketed drug is important in monitoring the efficacy or safety after a patient uses the drug. In this article, we clarify the statistical definitions of the surrogate endpoint and surrogate marker and introduce the concept of the validity and efficiency of a surrogate marker. We also review some existing methods and suggest the proportion of information gain is appropriate to be used to evaluate the validity of a surrogate marker.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Qu, Yongming}, biburl = {https://www.bibsonomy.org/bibtex/2288ab61681b26f3fdbd4e148b5a1a71d/jepcastel}, doi = {10.1177/1740774513499652}, interhash = {2ac217769bacb4bcccac82a6104bff52}, intrahash = {288ab61681b26f3fdbd4e148b5a1a71d}, issn = {1740-7753}, journal = {Clinical trials (London, England)}, keywords = {imported}, month = {10}, note = {Mesures de resultats; Surrogate endpoints; Introductori}, number = 5, pages = {693-5}, pmid = {23988465}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Statistical evaluation of surrogate markers: validity, efficiency, and sensitivity.}, url = {http://journals.sagepub.com/doi/10.1177/1740774513499652 http://www.ncbi.nlm.nih.gov/pubmed/23988465}, volume = 10, year = 2013 }