Premature delivery is still a significant problem in Obstetrics. It has multiple causes, with around 50\% thought due to infection. Of note infection as a pathogenesis is more likely in those pre-term births occurring <30 weeks gestation and is largely sub-clinical. Potential pathogens largely arise from the ascending route and from the endogenous vaginal flora, causing chorioamnionitis. Resultant morbidity from the release of endo+/exotoxins from such pathogens, the stimulation and production of inflammatory cytokine pathways, prostaglandins, metalloproteinases includes maternal sepsis (chorioamnionitis, septicaemia, post-partum endometritis), pre-term delivery (infant pre-maturity and its consequences, increased susceptibility to cerebral palsy and neonatal sepsis). As well, infection increases mortality due to fetal loss (extreme pre-maturity) as well as severe neonatal sepsis.
%0 Journal Article
%1 Garland2002
%A Garland, Suzanne M
%A Chuileann?in, Fiona N?
%A Satzke, Catherine
%A Robins-Browne, Roy
%D 2002
%J J Reprod Immunol
%K Biological Markers; Cerebral Palsy; Female; Humans; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Streptococcal Infections; Streptococcus agalactiae; Trichomonas Vaginitis; Vaginosis, Bacterial
%N 1-2
%P 169--183
%T Mechanisms, organisms and markers of infection in pregnancy.
%V 57
%X Premature delivery is still a significant problem in Obstetrics. It has multiple causes, with around 50\% thought due to infection. Of note infection as a pathogenesis is more likely in those pre-term births occurring <30 weeks gestation and is largely sub-clinical. Potential pathogens largely arise from the ascending route and from the endogenous vaginal flora, causing chorioamnionitis. Resultant morbidity from the release of endo+/exotoxins from such pathogens, the stimulation and production of inflammatory cytokine pathways, prostaglandins, metalloproteinases includes maternal sepsis (chorioamnionitis, septicaemia, post-partum endometritis), pre-term delivery (infant pre-maturity and its consequences, increased susceptibility to cerebral palsy and neonatal sepsis). As well, infection increases mortality due to fetal loss (extreme pre-maturity) as well as severe neonatal sepsis.
@article{Garland2002,
abstract = {Premature delivery is still a significant problem in Obstetrics. It has multiple causes, with around 50\% thought due to infection. Of note infection as a pathogenesis is more likely in those pre-term births occurring <30 weeks gestation and is largely sub-clinical. Potential pathogens largely arise from the ascending route and from the endogenous vaginal flora, causing chorioamnionitis. Resultant morbidity from the release of endo+/exotoxins from such pathogens, the stimulation and production of inflammatory cytokine pathways, prostaglandins, metalloproteinases includes maternal sepsis (chorioamnionitis, septicaemia, post-partum endometritis), pre-term delivery (infant pre-maturity and its consequences, increased susceptibility to cerebral palsy and neonatal sepsis). As well, infection increases mortality due to fetal loss (extreme pre-maturity) as well as severe neonatal sepsis.},
added-at = {2014-07-19T19:31:20.000+0200},
author = {Garland, Suzanne M and Chuileann?in, Fiona N? and Satzke, Catherine and Robins-Browne, Roy},
biburl = {https://www.bibsonomy.org/bibtex/2b44b575191ff2fb747d956cf41ad4f42/ar0berts},
groups = {public},
interhash = {9923032ff3e437f14724c60069d26b6b},
intrahash = {b44b575191ff2fb747d956cf41ad4f42},
journal = {J Reprod Immunol},
keywords = {Biological Markers; Cerebral Palsy; Female; Humans; Infant, Newborn; Obstetric Labor, Premature; Pregnancy; Pregnancy Complications, Infectious; Streptococcal Infections; Streptococcus agalactiae; Trichomonas Vaginitis; Vaginosis, Bacterial},
number = {1-2},
pages = {169--183},
pii = {S0165037802000189},
pmid = {12385841},
timestamp = {2014-07-19T19:31:20.000+0200},
title = {Mechanisms, organisms and markers of infection in pregnancy.},
username = {ar0berts},
volume = 57,
year = 2002
}