The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years. All had a pre-treatment mean lower extremity Ashworth scores of >or= 3 and a significant reduction in tone after a bolus injection of intrathecal baclofen (ITB) and received an implanted pump for continuous delivery of ITB. Motor function was assessed by the Gross Motor Function Measure (GMFM) prior to and 1 year following pump implantation. Significant improvement (p < 0.05) in mean GMFM scores was seen in subjects < 8 years (mean change 4.1) and in those from 8-18 years (mean change 3.7) and in subjects with CP Classes 2 and 5 (mean changes 6.2 and 2.9). There was a statistically significant decrease (p < 0.05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved.
%0 Journal Article
%1 Krach2005
%A Krach, Linda E
%A Kriel, Robert L
%A Gilmartin, Richard C
%A Swift, Dale M
%A Storrs, Bruce B
%A Abbott, Rick
%A Ward, John D
%A Bloom, Karen K
%A Brooks, William H
%A Madsen, Joseph R
%A McLaughlin, John F
%A Nadell, Joseph M
%D 2005
%J Pediatr Rehabil
%K Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Injections, Spinal; Lower Extremity; Moto; Muscle Contraction; Relaxants, Central; Spasticity; Patient Satisfaction; Physical Endurance; Posture; Prospective r Activity
%N 3
%P 207--213
%R 10.1080/13638490400021479
%T GMFM 1 year after continuous intrathecal baclofen infusion.
%U http://dx.doi.org/10.1080/13638490400021479
%V 8
%X The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years. All had a pre-treatment mean lower extremity Ashworth scores of >or= 3 and a significant reduction in tone after a bolus injection of intrathecal baclofen (ITB) and received an implanted pump for continuous delivery of ITB. Motor function was assessed by the Gross Motor Function Measure (GMFM) prior to and 1 year following pump implantation. Significant improvement (p < 0.05) in mean GMFM scores was seen in subjects < 8 years (mean change 4.1) and in those from 8-18 years (mean change 3.7) and in subjects with CP Classes 2 and 5 (mean changes 6.2 and 2.9). There was a statistically significant decrease (p < 0.05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved.
@article{Krach2005,
abstract = {The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years. All had a pre-treatment mean lower extremity Ashworth scores of >or= 3 and a significant reduction in tone after a bolus injection of intrathecal baclofen (ITB) and received an implanted pump for continuous delivery of ITB. Motor function was assessed by the Gross Motor Function Measure (GMFM) prior to and 1 year following pump implantation. Significant improvement (p < 0.05) in mean GMFM scores was seen in subjects < 8 years (mean change 4.1) and in those from 8-18 years (mean change 3.7) and in subjects with CP Classes 2 and 5 (mean changes 6.2 and 2.9). There was a statistically significant decrease (p < 0.05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved.},
added-at = {2014-07-19T20:39:24.000+0200},
author = {Krach, Linda E and Kriel, Robert L and Gilmartin, Richard C and Swift, Dale M and Storrs, Bruce B and Abbott, Rick and Ward, John D and Bloom, Karen K and Brooks, William H and Madsen, Joseph R and McLaughlin, John F and Nadell, Joseph M},
biburl = {https://www.bibsonomy.org/bibtex/2b68edc845a2cdaad02fd791d1b632272/ar0berts},
doi = {10.1080/13638490400021479},
groups = {public},
interhash = {642cdd940fd5cf778fb28eb791966a8c},
intrahash = {b68edc845a2cdaad02fd791d1b632272},
journal = {Pediatr Rehabil},
keywords = {Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Injections, Spinal; Lower Extremity; Moto; Muscle Contraction; Relaxants, Central; Spasticity; Patient Satisfaction; Physical Endurance; Posture; Prospective r Activity},
number = 3,
pages = {207--213},
pii = {RD9W21W2PHWKEEU6},
pmid = {16087555},
timestamp = {2014-07-19T20:39:24.000+0200},
title = {GMFM 1 year after continuous intrathecal baclofen infusion.},
url = {http://dx.doi.org/10.1080/13638490400021479},
username = {ar0berts},
volume = 8,
year = 2005
}