The universality of calcium as an intracellular messenger depends on its
enormous versatility. Cells have a calcium signalling toolkit with many
components that can be mixed and matched to create a wide range of
spatial and temporal signals. This versatility is exploited to control
processes as diverse as fertilization, proliferation, development,
learning and memory, contraction and secretion, and must be accomplished
within the context of calcium being highly toxic. Exceeding its normal
spatial and temporal boundaries can result in cell death through both
necrosis and apoptosis.
%0 Journal Article
%1 ber-lip
%A Berridge, MJ
%A Lipp, P
%A Bootman, MD
%C HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
%D 2000
%I NATURE PUBLISHING GROUP
%J NATURE REVIEWS MOLECULAR CELL BIOLOGY
%K calcium
%N 1
%P 11-21
%R 10.1038/35036035
%T The versatility and universality of calcium signalling
%V 1
%X The universality of calcium as an intracellular messenger depends on its
enormous versatility. Cells have a calcium signalling toolkit with many
components that can be mixed and matched to create a wide range of
spatial and temporal signals. This versatility is exploited to control
processes as diverse as fertilization, proliferation, development,
learning and memory, contraction and secretion, and must be accomplished
within the context of calcium being highly toxic. Exceeding its normal
spatial and temporal boundaries can result in cell death through both
necrosis and apoptosis.
@article{ber-lip,
abstract = {{The universality of calcium as an intracellular messenger depends on its
enormous versatility. Cells have a calcium signalling toolkit with many
components that can be mixed and matched to create a wide range of
spatial and temporal signals. This versatility is exploited to control
processes as diverse as fertilization, proliferation, development,
learning and memory, contraction and secretion, and must be accomplished
within the context of calcium being highly toxic. Exceeding its normal
spatial and temporal boundaries can result in cell death through both
necrosis and apoptosis.}},
added-at = {2013-01-07T13:19:04.000+0100},
address = {{HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND}},
affiliation = {{Berridge, MJ (Reprint Author), Babraham Inst, Mol Signalling Lab, Babraham Hall, Cambridge CB2 4AT, England..
Babraham Inst, Mol Signalling Lab, Cambridge CB2 4AT, England.}},
author = {Berridge, MJ and Lipp, P and Bootman, MD},
biburl = {https://www.bibsonomy.org/bibtex/2b7f8e480b9e02571afa41aa693474faf/jehiorns},
doc-delivery-number = {{381LV}},
doi = {{10.1038/35036035}},
interhash = {a5bfeb16ed4e7c7a972c0d3b05de3da3},
intrahash = {b7f8e480b9e02571afa41aa693474faf},
issn = {{1471-0072}},
journal = {{NATURE REVIEWS MOLECULAR CELL BIOLOGY}},
journal-iso = {{Nat. Rev. Mol. Cell Biol.}},
keywords = {calcium},
keywords-plus = {{SMOOTH-MUSCLE CELLS; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR;
INTRACELLULAR FREE CALCIUM; PANCREATIC ACINAR-CELLS; XENOPUS-LAEVIS;
ENDOPLASMIC-RETICULUM; CA2+ RELEASE; PYRIDINE-NUCLEOTIDE; TYROSINE
KINASE; NUCLEAR CALCIUM}},
language = {{English}},
month = {{OCT}},
number = {{1}},
number-of-cited-references = {{112}},
pages = {{11-21}},
publisher = {{NATURE PUBLISHING GROUP}},
research-areas = {{Cell Biology}},
times-cited = {{2064}},
timestamp = {2013-01-07T13:19:04.000+0100},
title = {{The versatility and universality of calcium signalling}},
type = {{Review}},
unique-id = {{ISI:000165765100012}},
volume = {{1}},
web-of-science-categories = {{Cell Biology}},
year = {{2000}}
}