The deformation properties of submicrometric drug carriers can influence
their tissue-penetration ability and thus the drug targeting. The aim of
this study was to determine whether the oily core composition (raw oils
or a dispersion of oils and solid lipid) surrounded by a polymeric wall
poly(epsilon-caprolactone), (PCL) can affect the deformation
properties of nanocapsules (NCs) or lipid-core nanocapsules (LNCs).
Formulations were prepared as aqueous suspensions using a polymer and
either a mixture of caprylic/capric triglyceride (CCT) and octyl
methoxycinnamate (OMC) or a mixture of CCT, OMC and sorbitan
monostearate (SM) as core components, respectively. Formulations had
mean diameters close to 200 nm presenting monomodal distributions. A
polysorbate 80 coating rendered z-potential values close to zero, acting
as a steric stabilizer. Atomic force microscopy (AFM) showed, through
force curves analysis, that the cantilever deflection was more
pronounced for the LNCs than for the NCs. The same force applied to NC
produced an indentation around twice that observed for the LNCs. The
Young's modulus (E) values were 0.537 MPa (LNC) and 0.364 MPa (NC) considering conical geometry while E = 0.17 MPa (NC) and E = 0.241 (LNC)
for spherical geometry. These data confirm that the LNCs are stiffer
than the NCs. The rigidity of both the polymer wall and lipid core is
higher for LNCs. In conclusion, LNCs presented distinct mechanical
properties compared to the conventional polymeric NCs.
%0 Journal Article
%1 WOS:000293412900016
%A Fiel, Luana Almeida
%A Rebelo, Luciana Magalhaes
%A de Santiago, Thiago Melo
%A Adorne, Marcia Duarte
%A Guterres, Silvia Staniscuaski
%A de Sousa, Jeanlex Soares
%A Pohlmann, Adriana Raffin
%C THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
%D 2011
%I ROYAL SOC CHEMISTRY
%J SOFT MATTER
%K imported
%N 16
%P 7240-7247
%R 10.1039/c1sm05508a
%T Diverse deformation properties of polymeric nanocapsules and lipid-core
nanocapsules
%V 7
%X The deformation properties of submicrometric drug carriers can influence
their tissue-penetration ability and thus the drug targeting. The aim of
this study was to determine whether the oily core composition (raw oils
or a dispersion of oils and solid lipid) surrounded by a polymeric wall
poly(epsilon-caprolactone), (PCL) can affect the deformation
properties of nanocapsules (NCs) or lipid-core nanocapsules (LNCs).
Formulations were prepared as aqueous suspensions using a polymer and
either a mixture of caprylic/capric triglyceride (CCT) and octyl
methoxycinnamate (OMC) or a mixture of CCT, OMC and sorbitan
monostearate (SM) as core components, respectively. Formulations had
mean diameters close to 200 nm presenting monomodal distributions. A
polysorbate 80 coating rendered z-potential values close to zero, acting
as a steric stabilizer. Atomic force microscopy (AFM) showed, through
force curves analysis, that the cantilever deflection was more
pronounced for the LNCs than for the NCs. The same force applied to NC
produced an indentation around twice that observed for the LNCs. The
Young's modulus (E) values were 0.537 MPa (LNC) and 0.364 MPa (NC) considering conical geometry while E = 0.17 MPa (NC) and E = 0.241 (LNC)
for spherical geometry. These data confirm that the LNCs are stiffer
than the NCs. The rigidity of both the polymer wall and lipid core is
higher for LNCs. In conclusion, LNCs presented distinct mechanical
properties compared to the conventional polymeric NCs.
@article{WOS:000293412900016,
abstract = {The deformation properties of submicrometric drug carriers can influence
their tissue-penetration ability and thus the drug targeting. The aim of
this study was to determine whether the oily core composition (raw oils
or a dispersion of oils and solid lipid) surrounded by a polymeric wall
[poly(epsilon-caprolactone), (PCL)] can affect the deformation
properties of nanocapsules (NCs) or lipid-core nanocapsules (LNCs).
Formulations were prepared as aqueous suspensions using a polymer and
either a mixture of caprylic/capric triglyceride (CCT) and octyl
methoxycinnamate (OMC) or a mixture of CCT, OMC and sorbitan
monostearate (SM) as core components, respectively. Formulations had
mean diameters close to 200 nm presenting monomodal distributions. A
polysorbate 80 coating rendered z-potential values close to zero, acting
as a steric stabilizer. Atomic force microscopy (AFM) showed, through
force curves analysis, that the cantilever deflection was more
pronounced for the LNCs than for the NCs. The same force applied to NC
produced an indentation around twice that observed for the LNCs. The
Young's modulus (E) values were 0.537 MPa (LNC) and 0.364 MPa (NC) considering conical geometry while E = 0.17 MPa (NC) and E = 0.241 (LNC)
for spherical geometry. These data confirm that the LNCs are stiffer
than the NCs. The rigidity of both the polymer wall and lipid core is
higher for LNCs. In conclusion, LNCs presented distinct mechanical
properties compared to the conventional polymeric NCs.},
added-at = {2022-05-23T20:00:14.000+0200},
address = {THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND},
author = {Fiel, Luana Almeida and Rebelo, Luciana Magalhaes and de Santiago, Thiago Melo and Adorne, Marcia Duarte and Guterres, Silvia Staniscuaski and de Sousa, Jeanlex Soares and Pohlmann, Adriana Raffin},
biburl = {https://www.bibsonomy.org/bibtex/2ba8e00bdeb8fa9a0d03be431b772af00/ppgfis_ufc_br},
doi = {10.1039/c1sm05508a},
interhash = {0d7a4d0f5f287bab1466e18562318d85},
intrahash = {ba8e00bdeb8fa9a0d03be431b772af00},
issn = {1744-683X},
journal = {SOFT MATTER},
keywords = {imported},
number = 16,
pages = {7240-7247},
publisher = {ROYAL SOC CHEMISTRY},
pubstate = {published},
timestamp = {2022-05-23T20:00:14.000+0200},
title = {Diverse deformation properties of polymeric nanocapsules and lipid-core
nanocapsules},
tppubtype = {article},
volume = 7,
year = 2011
}