%0 Journal Article %1 Harding2004 %A Harding, David R %A Dhamrait, Sukbhir %A Whitelaw, Andrew %A Humphries, Steve E %A Marlow, Neil %A Montgomery, Hugh E %D 2004 %J Pediatrics %K Cerebral Hemorrhage; Palsy; Developmental Disabilities; Female; Genotype; Humans; Infant, Newborn; Premature; Premature, Diseases; Interleukin-6; Leukomalacia, Periventricular; Male; Severity of Illness Index %N 4 %P 941--947 %R 10.1542/peds.2003-0494-F %T Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth? %U http://dx.doi.org/10.1542/peds.2003-0494-F %V 114 %X OBJECTIVE: The severity of the proinflammatory response may determine outcome in the critically ill. Genetic variation in the promoter region of the gene encoding the proinflammatory cytokine interleukin-6 (IL-6; -174 CC genotype) may encode enhanced production of IL-6. Our objective was to determine whether the CC genotype is associated with worse early illness severity, neurologic injury, and lower developmental scores among surviving preterm children. METHODS: Genotype was determined from dried blood spots that were taken for neonatal screening tests 7 days or more after birth; outcome was independently assessed as part of a longitudinal study of children of < or =32 weeks' gestational age. RESULTS: CC genotype was associated with worse intensive care indices. Significant hemorrhagic brain injuries occurred in 5 (19\%) of 27 children with CC genotype compared with 7 (6\%) of 121 children with GC or GG genotype, and images consistent with white matter damage (ventriculomegaly or cystic periventricular leukomalacia) occurred in 9 (26\%) of CC patients compared with 9 (7\%) in GC/GG children. Disability occurred significantly more often in CC children: 8 (31\%) compared with 16 (13\%). A similar trend was also noted in children with cerebral palsy (15\% compared with 7\%, respectively). Developmental, cognitive, and motor scores at 2 years and 5.5 years were independent of genotype among children with or without disability. CONCLUSIONS: In a population of surviving children who were born at < or =32 weeks' gestational age, variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices.

@article{Harding2004, abstract = {OBJECTIVE: The severity of the proinflammatory response may determine outcome in the critically ill. Genetic variation in the promoter region of the gene encoding the proinflammatory cytokine interleukin-6 (IL-6; -174 CC genotype) may encode enhanced production of IL-6. Our objective was to determine whether the CC genotype is associated with worse early illness severity, neurologic injury, and lower developmental scores among surviving preterm children. METHODS: Genotype was determined from dried blood spots that were taken for neonatal screening tests 7 days or more after birth; outcome was independently assessed as part of a longitudinal study of children of < or =32 weeks' gestational age. RESULTS: CC genotype was associated with worse intensive care indices. Significant hemorrhagic brain injuries occurred in 5 (19\%) of 27 children with CC genotype compared with 7 (6\%) of 121 children with GC or GG genotype, and images consistent with white matter damage (ventriculomegaly or cystic periventricular leukomalacia) occurred in 9 (26\%) of CC patients compared with 9 (7\%) in GC/GG children. Disability occurred significantly more often in CC children: 8 (31\%) compared with 16 (13\%). A similar trend was also noted in children with cerebral palsy (15\% compared with 7\%, respectively). Developmental, cognitive, and motor scores at 2 years and 5.5 years were independent of genotype among children with or without disability. CONCLUSIONS: In a population of surviving children who were born at < or =32 weeks' gestational age, variation of the gene that may increase IL-6 synthesis is associated with disabling brain injury but not cognitive development despite association with worse early critical care indices.}, added-at = {2014-07-19T20:23:27.000+0200}, author = {Harding, David R and Dhamrait, Sukbhir and Whitelaw, Andrew and Humphries, Steve E and Marlow, Neil and Montgomery, Hugh E}, biburl = {https://www.bibsonomy.org/bibtex/2bdeaf200e3df63e64f6f10a6c4e82aff/ar0berts}, doi = {10.1542/peds.2003-0494-F}, groups = {public}, interhash = {e85951bfad4669a4b3f42081b8b71c5f}, intrahash = {bdeaf200e3df63e64f6f10a6c4e82aff}, journal = {Pediatrics}, keywords = {Cerebral Hemorrhage; Palsy; Developmental Disabilities; Female; Genotype; Humans; Infant, Newborn; Premature; Premature, Diseases; Interleukin-6; Leukomalacia, Periventricular; Male; Severity of Illness Index}, month = Oct, number = 4, pages = {941--947}, pii = {114/4/941}, pmid = {15466088}, timestamp = {2014-07-19T20:23:27.000+0200}, title = {Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth?}, url = {http://dx.doi.org/10.1542/peds.2003-0494-F}, username = {ar0berts}, volume = 114, year = 2004 }