OBJECTIVE: To estimate the risk for cerebral palsy in preterm infants in relation to the presence of meconium in the amniotic fluid (AF). METHODS: A cohort study was conducted of 404 consecutive preterm infants delivered between 24 and 33 weeks' gestation at a single institution. Sociodemographic and clinical data were collected at birth. The diagnosis of cerebral palsy was made at 2 years' corrected age. Politomous logistic regression models were used to evaluate the odds for cerebral palsy while adjusting for potential confounders. RESULTS: The overall prevalence of cerebral palsy among survivors was 11.6\% (40/345). The cerebral palsy rate was 41.2\% (7/17) among infants who were meconium-stained at birth and 10\% (33/328) among those who were not (P = .006 by Fisher exact test). After adjustment for potential confounders (gestational age and fetal gender), the odds ratio of cerebral palsy among infants delivered to women with meconium-stained AF was 6.9 (95\% confidence interval 2.32, 20.81, P = .001) relative to those delivered to women with clear AF. CONCLUSION: The results of the present study support the view that the presence of meconium in the AF is a gestational age-independent risk factor for cerebral palsy among preterm infants.
%0 Journal Article
%1 Spinillo1997
%A Spinillo, A.
%A Fazzi, E.
%A Capuzzo, E.
%A Stronati, M.
%A Piazzi, G.
%A Ferrari, A.
%D 1997
%J Obstet Gynecol
%K Amniotic Fluid; Cerebral Palsy; Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Premature, Diseases; Logistic Models; Meconium; Prevalence; Risk Factors; Socioeconomic Factors
%N 4 Pt 1
%P 519--523
%T Meconium-stained amniotic fluid and risk for cerebral palsy in preterm infants.
%V 90
%X OBJECTIVE: To estimate the risk for cerebral palsy in preterm infants in relation to the presence of meconium in the amniotic fluid (AF). METHODS: A cohort study was conducted of 404 consecutive preterm infants delivered between 24 and 33 weeks' gestation at a single institution. Sociodemographic and clinical data were collected at birth. The diagnosis of cerebral palsy was made at 2 years' corrected age. Politomous logistic regression models were used to evaluate the odds for cerebral palsy while adjusting for potential confounders. RESULTS: The overall prevalence of cerebral palsy among survivors was 11.6\% (40/345). The cerebral palsy rate was 41.2\% (7/17) among infants who were meconium-stained at birth and 10\% (33/328) among those who were not (P = .006 by Fisher exact test). After adjustment for potential confounders (gestational age and fetal gender), the odds ratio of cerebral palsy among infants delivered to women with meconium-stained AF was 6.9 (95\% confidence interval 2.32, 20.81, P = .001) relative to those delivered to women with clear AF. CONCLUSION: The results of the present study support the view that the presence of meconium in the AF is a gestational age-independent risk factor for cerebral palsy among preterm infants.
@article{Spinillo1997,
abstract = {OBJECTIVE: To estimate the risk for cerebral palsy in preterm infants in relation to the presence of meconium in the amniotic fluid (AF). METHODS: A cohort study was conducted of 404 consecutive preterm infants delivered between 24 and 33 weeks' gestation at a single institution. Sociodemographic and clinical data were collected at birth. The diagnosis of cerebral palsy was made at 2 years' corrected age. Politomous logistic regression models were used to evaluate the odds for cerebral palsy while adjusting for potential confounders. RESULTS: The overall prevalence of cerebral palsy among survivors was 11.6\% (40/345). The cerebral palsy rate was 41.2\% (7/17) among infants who were meconium-stained at birth and 10\% (33/328) among those who were not (P = .006 by Fisher exact test). After adjustment for potential confounders (gestational age and fetal gender), the odds ratio of cerebral palsy among infants delivered to women with meconium-stained AF was 6.9 (95\% confidence interval 2.32, 20.81, P = .001) relative to those delivered to women with clear AF. CONCLUSION: The results of the present study support the view that the presence of meconium in the AF is a gestational age-independent risk factor for cerebral palsy among preterm infants.},
added-at = {2014-07-19T21:22:55.000+0200},
author = {Spinillo, A. and Fazzi, E. and Capuzzo, E. and Stronati, M. and Piazzi, G. and Ferrari, A.},
biburl = {https://www.bibsonomy.org/bibtex/2be4ba437c283465a02ff27248de8f0ec/ar0berts},
groups = {public},
interhash = {09b35e56fa290baa4f6226ab144ee506},
intrahash = {be4ba437c283465a02ff27248de8f0ec},
journal = {Obstet Gynecol},
keywords = {Amniotic Fluid; Cerebral Palsy; Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Premature, Diseases; Logistic Models; Meconium; Prevalence; Risk Factors; Socioeconomic Factors},
month = Oct,
number = {4 Pt 1},
pages = {519--523},
pmid = {9380308},
timestamp = {2014-07-19T21:22:55.000+0200},
title = {Meconium-stained amniotic fluid and risk for cerebral palsy in preterm infants.},
username = {ar0berts},
volume = 90,
year = 1997
}