Lysergic Acid Diethylamide (LSD-25): XXXVI. Comparison of effect of methysergide (UML 491) on goldfish and Siamese fighting fish
Journal of Psychology: Interdisciplinary and Applied, (1965)Abstract
Methysergide (UML-491) is marketed in the U.S. under the trade name of Sansert. It is widely used in man for the treatment of headache. Methysergide differs from LSD-25 by the presence of a methyl group on the indole nitrogen and by the substitution of butanol for the 2 ethyl groups on the amide linkage. The effect of methysergide on goldfish and Siamese fighting fish discloses that both react to methysergide in the same way they react to LSD-25. The increase in the quantity of methysergide needed to obtain the reaction of fish is approximately equal to that increase required to obtain psychic effects in a limited number of test Ss. Mystery snails react to methysergide in the way they react to LSD-25 except that higher doses of methysergide are required. It is believed that methysergide and LSD-25 act on somewhat similar enzyme systems. (PsycINFO Database Record (c) 2004 APA, all rights reserved)