%0 Journal Article %1 Wiles2010Building %A Wiles, Amy M. %A Doderer, Mark %A Ruan, Jianhua %A Gu, Ting-Ting %A Ravi, Dashnamoorthy %A Blackman, Barron %A Bishop, Alexander J. R. %D 2010 %I BioMed Central Ltd %J BMC Systems Biology %K comparative-analysis interactome protein-protein-interactions %N 1 %P 36+ %R 10.1186/1752-0509-4-36 %T Building and analyzing protein interactome networks by cross-species comparisons %U http://dx.doi.org/10.1186/1752-0509-4-36 %V 4 %X A genomic catalogue of protein-protein interactions is a rich source of information, particularly for exploring the relationships between proteins. Numerous systems-wide and small-scale experiments have been conducted to identify interactions; however, our knowledge of all interactions for any one species is incomplete, and alternative means to expand these network maps is needed. We therefore took a comparative biology approach to predict protein-protein interactions across five species (human, mouse, fly, worm, and yeast) and developed InterologFinder for research biologists to easily navigate this data. We also developed a confidence score for interactions based on available experimental evidence and conservation across species.

@article{Wiles2010Building, abstract = {A genomic catalogue of protein-protein interactions is a rich source of information, particularly for exploring the relationships between proteins. Numerous systems-wide and small-scale experiments have been conducted to identify interactions; however, our knowledge of all interactions for any one species is incomplete, and alternative means to expand these network maps is needed. We therefore took a comparative biology approach to predict protein-protein interactions across five species (human, mouse, fly, worm, and yeast) and developed {InterologFinder} for research biologists to easily navigate this data. We also developed a confidence score for interactions based on available experimental evidence and conservation across species.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Wiles, Amy M. and Doderer, Mark and Ruan, Jianhua and Gu, Ting-Ting and Ravi, Dashnamoorthy and Blackman, Barron and Bishop, Alexander J. R.}, biburl = {https://www.bibsonomy.org/bibtex/2c04b7c684b60e164025e61f9721cc4a9/karthikraman}, citeulike-article-id = {6930635}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/1752-0509-4-36}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/20353594}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=20353594}, day = 30, doi = {10.1186/1752-0509-4-36}, interhash = {ecbfe437e9c9a2cfc20abd36276cbe80}, intrahash = {c04b7c684b60e164025e61f9721cc4a9}, issn = {1752-0509}, journal = {BMC Systems Biology}, keywords = {comparative-analysis interactome protein-protein-interactions}, month = mar, number = 1, pages = {36+}, pmid = {20353594}, posted-at = {2010-03-31 09:48:47}, priority = {2}, publisher = {BioMed Central Ltd}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Building and analyzing protein interactome networks by cross-species comparisons}, url = {http://dx.doi.org/10.1186/1752-0509-4-36}, volume = 4, year = 2010 }