%0 Journal Article %1 Denays1990 %A Denays, R. %A Tondeur, M. %A Toppet, V. %A Ham, H. %A Piepsz, A. %A Spehl, M. %A Rubinstein, M. %A Noel, P. %D 1990 %J Radiology %K Brain; Cerebral Palsy; Cerebrovascular Circulation; Child; Child, Preschool; Female; Humans; Infant; Male; Organotechnetium Compounds; Oximes; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon %N 1 %P 111--116 %T Cerebral palsy: initial experience with Tc-99m HMPAO SPECT of the brain. %V 175 %X The outlook for children with cerebral palsy is determined by the severity of motor problems and the presence of associated disabilities, in which early detection remains a medical challenge. The authors studied 13 children (aged 13 months to 12 years) with cerebral palsy by means of single photon emission computed tomography (SPECT) of the brain with technetium-99m hexamethylpropyleneamineoxime (HMPAO). In all children with hemiplegia, SPECT demonstrated hypoperfusion in the hemisphere contralateral to the motor deficit. SPECT demonstrated normal findings in patients with mild diplegia; bilateral hypoperfusion in the superior motor cortex in patients with moderate di- or tetraplegia; and bilateral reduction of perfusion in the superior motor, inferior motor, prefrontal, and parietal cortices in patients with severe di- or tetraplegia. Results suggest that Tc-99m HMPAO SPECT of the brain is a valuable complementary tool for thorough neurologic assessment in cerebral palsy.

@article{Denays1990, abstract = {The outlook for children with cerebral palsy is determined by the severity of motor problems and the presence of associated disabilities, in which early detection remains a medical challenge. The authors studied 13 children (aged 13 months to 12 years) with cerebral palsy by means of single photon emission computed tomography (SPECT) of the brain with technetium-99m hexamethylpropyleneamineoxime (HMPAO). In all children with hemiplegia, SPECT demonstrated hypoperfusion in the hemisphere contralateral to the motor deficit. SPECT demonstrated normal findings in patients with mild diplegia; bilateral hypoperfusion in the superior motor cortex in patients with moderate di- or tetraplegia; and bilateral reduction of perfusion in the superior motor, inferior motor, prefrontal, and parietal cortices in patients with severe di- or tetraplegia. Results suggest that Tc-99m HMPAO SPECT of the brain is a valuable complementary tool for thorough neurologic assessment in cerebral palsy.}, added-at = {2014-07-19T19:18:42.000+0200}, author = {Denays, R. and Tondeur, M. and Toppet, V. and Ham, H. and Piepsz, A. and Spehl, M. and Rubinstein, M. and Noel, P.}, biburl = {https://www.bibsonomy.org/bibtex/2c2a9a5acea41da1c6e73971965a16458/ar0berts}, groups = {public}, interhash = {5445f690ae4d8299a8af2f0fb3e2d4f6}, intrahash = {c2a9a5acea41da1c6e73971965a16458}, journal = {Radiology}, keywords = {Brain; Cerebral Palsy; Cerebrovascular Circulation; Child; Child, Preschool; Female; Humans; Infant; Male; Organotechnetium Compounds; Oximes; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon}, month = Apr, number = 1, pages = {111--116}, pmid = {2315468}, timestamp = {2014-07-19T19:18:42.000+0200}, title = {Cerebral palsy: initial experience with Tc-99m HMPAO SPECT of the brain.}, username = {ar0berts}, volume = 175, year = 1990 }