%0 Generic %1 Reznik2010 %A Reznik, Ed %A Segrè, Daniel %D 2010 %K metabolism systems_biology %T On the Stability of Metabolic Cycles %U http://arxiv.org/abs/1001.1944 %X The stability properties of two different classes of metabolic cycles are investigated using a combination of analytical and computational techniques. Using principles from structural kinetic modeling (SKM), it is shown that the stability of well-ordered metabolic networks can be studied using exclusively analytical techniques. The guaranteed stability of a class of single input, single output metabolic cycles is established. Next, parameter regimes for the stability of a small autocatalytic cycle are determined. It is demonstrated that analytical methods can be used to understand the relationship between kinetic parameters and stability, and that results from these analytical methods can be confirmed with computational experiments. Results suggest that elevated metabolite concentrations and certain crucial saturation parameters can strongly affect the stability of the entire metabolic cycle. These conclusions support the hypothesis that certain types of metabolic cycles may have played a role in the development of primitive metabolism despite the absence of regulatory machinery. Furthermore, the results suggest that the role of allosteric control mechanisms in biochemical networks may be greater than simply stabilizing the network.

@misc{Reznik2010, abstract = { The stability properties of two different classes of metabolic cycles are investigated using a combination of analytical and computational techniques. Using principles from structural kinetic modeling (SKM), it is shown that the stability of well-ordered metabolic networks can be studied using exclusively analytical techniques. The guaranteed stability of a class of single input, single output metabolic cycles is established. Next, parameter regimes for the stability of a small autocatalytic cycle are determined. It is demonstrated that analytical methods can be used to understand the relationship between kinetic parameters and stability, and that results from these analytical methods can be confirmed with computational experiments. Results suggest that elevated metabolite concentrations and certain crucial saturation parameters can strongly affect the stability of the entire metabolic cycle. These conclusions support the hypothesis that certain types of metabolic cycles may have played a role in the development of primitive metabolism despite the absence of regulatory machinery. Furthermore, the results suggest that the role of allosteric control mechanisms in biochemical networks may be greater than simply stabilizing the network. }, added-at = {2010-01-19T03:42:55.000+0100}, author = {Reznik, Ed and Segrè, Daniel}, biburl = {https://www.bibsonomy.org/bibtex/2c364001363139eabb8c0169f52b8a4f0/penkib}, description = {[1001.1944] On the Stability of Metabolic Cycles}, interhash = {0929aedcfdf0a8f387930ba949fc3d3f}, intrahash = {c364001363139eabb8c0169f52b8a4f0}, keywords = {metabolism systems_biology}, note = {cite arxiv:1001.1944 Comment: 22 pages, 7 figures, Submitted to Journal of Theoretical Biology}, timestamp = {2010-01-19T03:42:56.000+0100}, title = {On the Stability of Metabolic Cycles}, url = {http://arxiv.org/abs/1001.1944}, year = 2010 }