%0 Journal Article %1 mothe2013review %A Mothe, Andrea J. %A Tator, Charles H. %D 2013 %J International Journal of Developmental Neuroscience %K differentiation phd review stemcell transplantation %N 7 %P 701--713 %R http://dx.doi.org/10.1016/j.ijdevneu.2013.07.004 %T Review of transplantation of neural stem/progenitor cells for spinal cord injury %U http://www.sciencedirect.com/science/article/pii/S0736574813001123 %V 31 %X Abstract Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy for promoting tissue repair after SCI. Stem cells offer a renewable source of cells with inherent plasticity for tissue regeneration. Neural stem/progenitor cells (NSPCs) are multipotent cells that self-renew and are committed to the neural lineage, and thus, they are especially suited to \SCI\ repair. \NSPCs\ may differentiate into neural cells after transplantation into the injured spinal cord, replacing lost or damaged cells, providing trophic support, restoring connectivity, and facilitating regeneration. Here, we review experimental studies and considerations for clinical translation of \NSPC\ transplantation for SCI.

@article{mothe2013review, abstract = {Abstract Spinal cord injury (SCI) is a debilitating condition often resulting in paralysis, yet currently there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy for promoting tissue repair after SCI. Stem cells offer a renewable source of cells with inherent plasticity for tissue regeneration. Neural stem/progenitor cells (NSPCs) are multipotent cells that self-renew and are committed to the neural lineage, and thus, they are especially suited to \{SCI\} repair. \{NSPCs\} may differentiate into neural cells after transplantation into the injured spinal cord, replacing lost or damaged cells, providing trophic support, restoring connectivity, and facilitating regeneration. Here, we review experimental studies and considerations for clinical translation of \{NSPC\} transplantation for SCI. }, added-at = {2015-08-03T17:24:50.000+0200}, author = {Mothe, Andrea J. and Tator, Charles H.}, biburl = {https://www.bibsonomy.org/bibtex/2c9cf9767ba8591e866c5f10425b15f02/bkoch}, description = {Review of transplantation of neural stem/progenitor cells for spinal cord injury}, doi = {http://dx.doi.org/10.1016/j.ijdevneu.2013.07.004}, interhash = {6243255aa26cfe44720054137a21eb98}, intrahash = {c9cf9767ba8591e866c5f10425b15f02}, issn = {0736-5748}, journal = {International Journal of Developmental Neuroscience }, keywords = {differentiation phd review stemcell transplantation}, number = 7, pages = {701--713}, timestamp = {2015-08-03T17:24:50.000+0200}, title = {Review of transplantation of neural stem/progenitor cells for spinal cord injury }, url = {http://www.sciencedirect.com/science/article/pii/S0736574813001123}, volume = 31, year = 2013 }