OBJECTIVES: This study was performed to determine risk factors for cerebral palsy (CP) in monochorionic twins, especially with twin-to-twin transfusion syndrome (TTTS). METHODS: In 33 pathologically confirmed monochorionic pregnancies, we analyzed the incidence of cardiovascular and neurological complications. RESULTS: Seventeen cases were diagnosed as TTTS. Myocardial hypertrophy was detected in seven recipient twins of TTTS, but not found in the donor twins of TTTS or in non-TTTS. CP developed in six out of 29 in TTTS and one out of 32 in non-TTTS. In TTTS, all the cases with CP were seen in the recipient twins. The development of CP was significantly associated with cardiovascular complications such as myocardial hypertrophy and hydropic changes. CONCLUSIONS: Myocardial hypertrophy found in the recipient twins in TTTS seems to be a risk for developing CP later on, which may have implications in understanding the pathogenesis of CP.
%0 Journal Article
%1 Hyodo2003
%A Hyodo, H. M.
%A Unno, N.
%A Masuda, H.
%A Watanabe, T.
%A Kozuma, S.
%A Taketani, Y.
%D 2003
%J Int J Gynaecol Obstet
%K Adult; Cardiomyopathy, Hypertrophic; Cerebral Palsy; Chorion; Female; Fetal Diseases; Fetofetal Transfusion; Gestational Age; Humans; Infant; Infant, Newborn; Pregnancy; Prognosis; Retrospective Studies; Risk Factors
%N 1
%P 29--34
%T Myocardial hypertrophy of the recipient twins in twin-to-twin transfusion syndrome and cerebral palsy.
%V 80
%X OBJECTIVES: This study was performed to determine risk factors for cerebral palsy (CP) in monochorionic twins, especially with twin-to-twin transfusion syndrome (TTTS). METHODS: In 33 pathologically confirmed monochorionic pregnancies, we analyzed the incidence of cardiovascular and neurological complications. RESULTS: Seventeen cases were diagnosed as TTTS. Myocardial hypertrophy was detected in seven recipient twins of TTTS, but not found in the donor twins of TTTS or in non-TTTS. CP developed in six out of 29 in TTTS and one out of 32 in non-TTTS. In TTTS, all the cases with CP were seen in the recipient twins. The development of CP was significantly associated with cardiovascular complications such as myocardial hypertrophy and hydropic changes. CONCLUSIONS: Myocardial hypertrophy found in the recipient twins in TTTS seems to be a risk for developing CP later on, which may have implications in understanding the pathogenesis of CP.
@article{Hyodo2003,
abstract = {OBJECTIVES: This study was performed to determine risk factors for cerebral palsy (CP) in monochorionic twins, especially with twin-to-twin transfusion syndrome (TTTS). METHODS: In 33 pathologically confirmed monochorionic pregnancies, we analyzed the incidence of cardiovascular and neurological complications. RESULTS: Seventeen cases were diagnosed as TTTS. Myocardial hypertrophy was detected in seven recipient twins of TTTS, but not found in the donor twins of TTTS or in non-TTTS. CP developed in six out of 29 in TTTS and one out of 32 in non-TTTS. In TTTS, all the cases with CP were seen in the recipient twins. The development of CP was significantly associated with cardiovascular complications such as myocardial hypertrophy and hydropic changes. CONCLUSIONS: Myocardial hypertrophy found in the recipient twins in TTTS seems to be a risk for developing CP later on, which may have implications in understanding the pathogenesis of CP.},
added-at = {2014-07-19T20:29:11.000+0200},
author = {Hyodo, H. M. and Unno, N. and Masuda, H. and Watanabe, T. and Kozuma, S. and Taketani, Y.},
biburl = {https://www.bibsonomy.org/bibtex/2d0368a09b64922858e2474ff7f9661da/ar0berts},
groups = {public},
interhash = {45394d2a91abf4d129622910409a6a51},
intrahash = {d0368a09b64922858e2474ff7f9661da},
journal = {Int J Gynaecol Obstet},
keywords = {Adult; Cardiomyopathy, Hypertrophic; Cerebral Palsy; Chorion; Female; Fetal Diseases; Fetofetal Transfusion; Gestational Age; Humans; Infant; Infant, Newborn; Pregnancy; Prognosis; Retrospective Studies; Risk Factors},
month = Jan,
number = 1,
pages = {29--34},
pii = {S0020729202002527},
pmid = {12527457},
timestamp = {2014-07-19T20:29:11.000+0200},
title = {Myocardial hypertrophy of the recipient twins in twin-to-twin transfusion syndrome and cerebral palsy.},
username = {ar0berts},
volume = 80,
year = 2003
}