Thirty-four adults were vaccinated with 1/50 of the usual dose of meningococcal polysaccharide vaccine (1 microg of A, C, Y, and W135 polysaccharides, given intramuscularly). This dose was selected as a probe to assess B cell memory. The probe elicited meningococcal C bactericidal antibody responses in all 18 adults who had been vaccinated 4 years earlier with an investigational meningococcal A and C oligosaccharide-protein conjugate vaccine and in the majority of the 11 subjects vaccinated for the first time. In contrast, the responses of the 5 adults given a full dose of licensed polysaccharide vaccine 4 years earlier were \textless1/10 of those of the other 2 groups. Thus, adults previously given a full dose of meningococcal polysaccharide vaccine show evidence of immunologic refractoriness to group C polysaccharide, whereas refractoriness is not observed after conjugate vaccination. These findings have implications for the use of meningococcal polysaccharide vaccine when the risk of disease is low.
%0 Journal Article
%1 granoff_induction_1998
%A Granoff, D M
%A Gupta, R K
%A Belshe, R B
%A Anderson, E L
%D 1998
%J The Journal of Infectious Diseases
%K Adult, Aged, Antibodies, Bacterial Bacterial, Conjugate Humans, Meningococcal Middle Neisseria Polysaccharides, Vaccination, Vaccines, meningitidis,
%N 3
%P 870--4
%R 9728562
%T Induction of immunologic refractoriness in adults by meningococcal C polysaccharide vaccination
%U http://www.ncbi.nlm.nih.gov/pubmed/9728562
%V 178
%X Thirty-four adults were vaccinated with 1/50 of the usual dose of meningococcal polysaccharide vaccine (1 microg of A, C, Y, and W135 polysaccharides, given intramuscularly). This dose was selected as a probe to assess B cell memory. The probe elicited meningococcal C bactericidal antibody responses in all 18 adults who had been vaccinated 4 years earlier with an investigational meningococcal A and C oligosaccharide-protein conjugate vaccine and in the majority of the 11 subjects vaccinated for the first time. In contrast, the responses of the 5 adults given a full dose of licensed polysaccharide vaccine 4 years earlier were \textless1/10 of those of the other 2 groups. Thus, adults previously given a full dose of meningococcal polysaccharide vaccine show evidence of immunologic refractoriness to group C polysaccharide, whereas refractoriness is not observed after conjugate vaccination. These findings have implications for the use of meningococcal polysaccharide vaccine when the risk of disease is low.
@article{granoff_induction_1998,
abstract = {Thirty-four adults were vaccinated with 1/50 of the usual dose of meningococcal polysaccharide vaccine (1 microg of A, C, Y, and W135 polysaccharides, given intramuscularly). This dose was selected as a probe to assess B cell memory. The probe elicited meningococcal C bactericidal antibody responses in all 18 adults who had been vaccinated 4 years earlier with an investigational meningococcal A and C oligosaccharide-protein conjugate vaccine and in the majority of the 11 subjects vaccinated for the first time. In contrast, the responses of the 5 adults given a full dose of licensed polysaccharide vaccine 4 years earlier were {\textless}1/10 of those of the other 2 groups. Thus, adults previously given a full dose of meningococcal polysaccharide vaccine show evidence of immunologic refractoriness to group C polysaccharide, whereas refractoriness is not observed after conjugate vaccination. These findings have implications for the use of meningococcal polysaccharide vaccine when the risk of disease is low.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Granoff, D M and Gupta, R K and Belshe, R B and Anderson, E L},
biburl = {https://www.bibsonomy.org/bibtex/2d8978ebb8e1009ba37bb05526545cfd7/jelias},
doi = {9728562},
interhash = {d163c4735bac858b0b31083f66cc1f5d},
intrahash = {d8978ebb8e1009ba37bb05526545cfd7},
issn = {0022-1899},
journal = {The Journal of Infectious Diseases},
keywords = {Adult, Aged, Antibodies, Bacterial Bacterial, Conjugate Humans, Meningococcal Middle Neisseria Polysaccharides, Vaccination, Vaccines, meningitidis,},
month = sep,
note = {{PMID:} 9728562},
number = 3,
pages = {870--4},
timestamp = {2011-03-11T10:06:09.000+0100},
title = {Induction of immunologic refractoriness in adults by meningococcal C polysaccharide vaccination},
url = {http://www.ncbi.nlm.nih.gov/pubmed/9728562},
volume = 178,
year = 1998
}