%0 Book Section %1 statphys23_0390 %A Jensen, M.H. %B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics %C Genova, Italy %D 2007 %E Pietronero, Luciano %E Loreto, Vittorio %E Zapperi, Stefano %K feed-back genetic loops networks oscillations protein statphys23 topic-10 %T Oscillations and temporal signalling in cells %U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=390 %X The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems which display regular oscillations in protein concentration. We discuss the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models. We focus on three genetic regulatory networks which show ultradian oscillations with time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53)and immune response (NF-kB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.

@incollection{statphys23_0390, abstract = {The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems which display regular oscillations in protein concentration. We discuss the different mechanisms which can produce oscillations in gene expression or protein concentration, using a framework of simple mathematical models. We focus on three genetic regulatory networks which show ultradian oscillations with time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53)and immune response (NF-kB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.}, added-at = {2007-06-20T10:16:09.000+0200}, address = {Genova, Italy}, author = {Jensen, M.H.}, biburl = {https://www.bibsonomy.org/bibtex/2e66a6b5489bf1ae7569500e53d51ec41/statphys23}, booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics}, editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano}, interhash = {be2470a762d4ec1ea145395b72a959fb}, intrahash = {e66a6b5489bf1ae7569500e53d51ec41}, keywords = {feed-back genetic loops networks oscillations protein statphys23 topic-10}, month = {9-13 July}, timestamp = {2007-06-20T10:16:19.000+0200}, title = {Oscillations and temporal signalling in cells}, url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=390}, year = 2007 }