Background: Several studies validated the positive impacts of Cholecalciferol derivatives; including dietary and non-dietary sources, on the bone architectural contents and the overall skeleton densities. We primarily aimed in this study to explore the optimal thresholds for the studied patients’ 25-OH Cholecalciferol levels that are correlated with the higher probabilities for having lumbar bone mineral density (LBMD) exceeding 0.835 g per cm2 and femoral hip bone mineral density (fH_BMD) exceeding 0.755 g per cm2.
Methods: An observational retrospective study was conducted for patients, who are at risk of osteoporotic fracture, Firstly, a Binary Logistic Regression analysis was separately conducted for the investigated patients’ vitamin D levels against the patients’ fH_BMD ≥0.755 (Positive state) vs <0.755 (Negative state) and against the patients’ LBMD≥ 0.835 (Positive state) vs <0.835 (Negative state). Both the Receiver Operating Characteristic and the Sensitivity analyses were thereafter be conducted and the performances indices were explored.
Results: Our constructed BLgR models, that logistically integrated the binary correlation between the investigated patients’ Vit D levels and their femoral hip or lumbar bone mineral densities, respectively, were constructed as = e (--1.455+0.109× Vit D) /1+ e (--1.455+0.109× Vit D) or = e (--22.127+0.829× Vit D) /1+ e (--22.127+0.829× Vit D), respectively.
Conclusion: The optimal Vitamin D levels for our investigated Jordanian cohort to have a higher probability of lumber and femoral hip bone mineral; densities were identified at 27.05 ng/ml and 27.25 ng/ml, respectively.
%0 Journal Article
%1 hayat_yaser_abdalraheem_hilan_2024_10685923
%A Hilan, Hayat Yaser Abdalraheem
%A Al-Tarawneh, Haneen Anwar Salameh
%A Jweinat, Manar Nader Ibraheem
%A al qiam, Safa Hassan Ahmad
%A Alkhalailah, Aishah Awwad Flaih
%A Alboun, Samer Mahmoud Mohammad Ali
%D 2024
%J World Journal of Biology Pharmacy and Health Sciences
%K D Vitamin levels
%N 2
%P 263–269
%R 10.30574/wjbphs.2023.15.2.0352
%T The vitamin- D quantity versus bone quality: A logistic based regression modeling in Jordanian cohort who at higher risk of osteoporotic fracture
%U https://wjbphs.com/content/vitamin-d-quantity-versus-bone-quality-logistic-based-regression-modeling-jordanian-cohort
%V 15
%X Background: Several studies validated the positive impacts of Cholecalciferol derivatives; including dietary and non-dietary sources, on the bone architectural contents and the overall skeleton densities. We primarily aimed in this study to explore the optimal thresholds for the studied patients’ 25-OH Cholecalciferol levels that are correlated with the higher probabilities for having lumbar bone mineral density (LBMD) exceeding 0.835 g per cm2 and femoral hip bone mineral density (fH_BMD) exceeding 0.755 g per cm2.
Methods: An observational retrospective study was conducted for patients, who are at risk of osteoporotic fracture, Firstly, a Binary Logistic Regression analysis was separately conducted for the investigated patients’ vitamin D levels against the patients’ fH_BMD ≥0.755 (Positive state) vs <0.755 (Negative state) and against the patients’ LBMD≥ 0.835 (Positive state) vs <0.835 (Negative state). Both the Receiver Operating Characteristic and the Sensitivity analyses were thereafter be conducted and the performances indices were explored.
Results: Our constructed BLgR models, that logistically integrated the binary correlation between the investigated patients’ Vit D levels and their femoral hip or lumbar bone mineral densities, respectively, were constructed as = e (--1.455+0.109× Vit D) /1+ e (--1.455+0.109× Vit D) or = e (--22.127+0.829× Vit D) /1+ e (--22.127+0.829× Vit D), respectively.
Conclusion: The optimal Vitamin D levels for our investigated Jordanian cohort to have a higher probability of lumber and femoral hip bone mineral; densities were identified at 27.05 ng/ml and 27.25 ng/ml, respectively.
@article{hayat_yaser_abdalraheem_hilan_2024_10685923,
abstract = {Background: Several studies validated the positive impacts of Cholecalciferol derivatives; including dietary and non-dietary sources, on the bone architectural contents and the overall skeleton densities. We primarily aimed in this study to explore the optimal thresholds for the studied patients’ 25-OH Cholecalciferol levels that are correlated with the higher probabilities for having lumbar bone mineral density (LBMD) exceeding 0.835 g per cm2 and femoral hip bone mineral density (fH_BMD) exceeding 0.755 g per cm2.
Methods: An observational retrospective study was conducted for patients, who are at risk of osteoporotic fracture, Firstly, a Binary Logistic Regression analysis was separately conducted for the investigated patients’ vitamin D levels against the patients’ fH_BMD ≥0.755 (Positive state) vs <0.755 (Negative state) and against the patients’ LBMD≥ 0.835 (Positive state) vs <0.835 (Negative state). Both the Receiver Operating Characteristic and the Sensitivity analyses were thereafter be conducted and the performances indices were explored.
Results: Our constructed BLgR models, that logistically integrated the binary correlation between the investigated patients’ Vit D levels and their femoral hip or lumbar bone mineral densities, respectively, were constructed as [= e (--1.455+0.109× Vit D) /1+ e (--1.455+0.109× Vit D)] or [= e (--22.127+0.829× Vit D) /1+ e (--22.127+0.829× Vit D)], respectively.
Conclusion: The optimal Vitamin D levels for our investigated Jordanian cohort to have a higher probability of lumber and femoral hip bone mineral; densities were identified at 27.05 ng/ml and 27.25 ng/ml, respectively.},
added-at = {2024-03-17T09:27:23.000+0100},
author = {Hilan, Hayat Yaser Abdalraheem and Al-Tarawneh, Haneen Anwar Salameh and Jweinat, Manar Nader Ibraheem and al qiam, Safa Hassan Ahmad and Alkhalailah, Aishah Awwad Flaih and Alboun, Samer Mahmoud Mohammad Ali},
biburl = {https://www.bibsonomy.org/bibtex/2e721ad2621061613072a14d2826ba2e3/wjbphsjournal},
doi = {10.30574/wjbphs.2023.15.2.0352},
interhash = {52153537c60452de46732073c8b12efe},
intrahash = {e721ad2621061613072a14d2826ba2e3},
issn = {2582-5542},
journal = {{World Journal of Biology Pharmacy and Health Sciences}},
keywords = {D Vitamin levels},
month = feb,
number = 2,
pages = {263–269},
timestamp = {2024-03-17T09:27:23.000+0100},
title = {The vitamin- D quantity versus bone quality: A logistic based regression modeling in Jordanian cohort who at higher risk of osteoporotic fracture},
url = {https://wjbphs.com/content/vitamin-d-quantity-versus-bone-quality-logistic-based-regression-modeling-jordanian-cohort},
volume = 15,
year = 2024
}