%0 Journal Article %1 brooker2021safety %A Brooker, Christa %A Sanders, Corrie %A Jia, Lily %A Goins, Tyler %A Nadpara, Pramit %A Almohaish, Sulaiman %A Brophy, Gretchen M %D 2021 %J Advances in Preventive Medicine and Health Care (ISSN: 2688-996X) %K Aneurysmal Hemorrhage Nimodipine Subarachnoid %N 3 %P 5 %R https://doi.org/10.29011/2574-7258.010106 %T Safety of Nimodipine in Critically Ill Aneurysmal Subarachnoid Hemorrhage Patients %U https://www.gavinpublishers.com/article/view/safety-of-nimodipine-in-critically-ill-aneurysmal-subarachnoid-hemorrhage-patients %V 6 %X Background: Nimodipine Oral Capsules (NOC) and Oral Solution (NOS) are used to prevent delayed cerebral ischemia in patients following an aneurysmal subarachnoid hemorrhage (aSAH). Due to increased reports of diarrhea with NOS, Virginia Commonwealth University Health (VCUH) now uses NOC and compounded oral syringes for dose administration. This study evaluates the safety of NOC and NOS in the treatment of critically ill aSAH patients admitted to the Intensive Care Unit. Methods: A retrospective chart review was performed for aSAH patients receiving NOC or NOS from June 1, 2013 to December 31, 2015 to evaluate the incidence of adverse drug reactions (ADRs) for NOS and NOC, including diarrhea, decreases in SystolicBlood Pressure (SBP), and SBP-associated nimodipine dosage adjustments. Results: Of patients receiving NOS, 82% experienced diarrhea compared to 52% who received NOC (p=0.02). Of the 69 patients who experienced diarrhea, 94% received at least one agent that is commonly associated with diarrhea. Overall, 92.7% of NOC patients experienced a median SBP reduction of 35 mmHg compared to 22 mm Hg receiving NOS (p=0.06). Doses were decreased from 60 mg to 30 mg in 61% of NOC patients versus 24% of NOS patients (p= 0.18) Conclusion: Critically ill aSAH patients receiving NOS were more likely to develop diarrhea compared to those receiving NOC. Most patients experiencing diarrhea received at least one concomitant medication associated with diarrhea. There was a clinically significant reduction in median SBP observed for both formulations and a majority of patients required dosage adjustments.

@article{brooker2021safety, abstract = {Background: Nimodipine Oral Capsules (NOC) and Oral Solution (NOS) are used to prevent delayed cerebral ischemia in patients following an aneurysmal subarachnoid hemorrhage (aSAH). Due to increased reports of diarrhea with NOS, Virginia Commonwealth University Health (VCUH) now uses NOC and compounded oral syringes for dose administration. This study evaluates the safety of NOC and NOS in the treatment of critically ill aSAH patients admitted to the Intensive Care Unit. Methods: A retrospective chart review was performed for aSAH patients receiving NOC or NOS from June 1, 2013 to December 31, 2015 to evaluate the incidence of adverse drug reactions (ADRs) for NOS and NOC, including diarrhea, decreases in SystolicBlood Pressure (SBP), and SBP-associated nimodipine dosage adjustments. Results: Of patients receiving NOS, 82% experienced diarrhea compared to 52% who received NOC (p=0.02). Of the 69 patients who experienced diarrhea, 94% received at least one agent that is commonly associated with diarrhea. Overall, 92.7% of NOC patients experienced a median SBP reduction of 35 mmHg compared to 22 mm Hg receiving NOS (p=0.06). Doses were decreased from 60 mg to 30 mg in 61% of NOC patients versus 24% of NOS patients (p= 0.18) Conclusion: Critically ill aSAH patients receiving NOS were more likely to develop diarrhea compared to those receiving NOC. Most patients experiencing diarrhea received at least one concomitant medication associated with diarrhea. There was a clinically significant reduction in median SBP observed for both formulations and a majority of patients required dosage adjustments.}, added-at = {2021-11-11T11:06:56.000+0100}, author = {Brooker, Christa and Sanders, Corrie and Jia, Lily and Goins, Tyler and Nadpara, Pramit and Almohaish, Sulaiman and Brophy, Gretchen M}, biburl = {https://www.bibsonomy.org/bibtex/2f0231a7a57d46839c7e283c958a7473b/alyssacarter}, doi = {https://doi.org/10.29011/2574-7258.010106}, interhash = {e700885b357695ac96cf74247bfe8c68}, intrahash = {f0231a7a57d46839c7e283c958a7473b}, issn = {2688-996X}, journal = {Advances in Preventive Medicine and Health Care (ISSN: 2688-996X)}, keywords = {Aneurysmal Hemorrhage Nimodipine Subarachnoid}, language = {ENGLISH}, month = {October}, number = 3, pages = 5, timestamp = {2021-11-11T11:06:56.000+0100}, title = {Safety of Nimodipine in Critically Ill Aneurysmal Subarachnoid Hemorrhage Patients}, url = {https://www.gavinpublishers.com/article/view/safety-of-nimodipine-in-critically-ill-aneurysmal-subarachnoid-hemorrhage-patients}, volume = 6, year = 2021 }