Abnormalities of the central nervous system are frequently described in optic nerve hypoplasia. In a longitudinal study of 46 consecutive children (32 term, 14 preterm) with bilateral optic nerve hypoplasia 32 (69.5\%) had associated neurodevelopmental handicap. Of these, 90\% had structural central nervous system abnormalities on computed tomographic brain scans. Neurodevelopmental handicap occurred in 62.5\% of the term and 86\% of the preterm infants respectively. Term infants had a greater incidence of ventral developmental midline defects and proportionately fewer maternal and/or neonatal complications throughout pregnancy, while encephaloclastic lesions were commoner among the premature infants. An association of optic nerve hypoplasia with the twin transfusion syndrome and prenatal vascular encephalopathies is described.
%0 Journal Article
%1 Burke1991
%A Burke, J. P.
%A O'Keefe, M.
%A Bowell, R.
%D 1991
%J Br J Ophthalmol
%K Abnormalities, Multiple; Brain; Cerebral Palsy; Child; Child, Preschool; Epilepsy; Evoked Potentials, Visual; Female; Fetofetal Transfusion; Gestational Age; Humans; Infant; Infant, Newbor; Longitudinal Studies; Male; Mental Retardation; Optic Nerve; Pregnancy; Visual Acuity; n
%N 4
%P 236--239
%T Optic nerve hypoplasia, encephalopathy, and neurodevelopmental handicap.
%V 75
%X Abnormalities of the central nervous system are frequently described in optic nerve hypoplasia. In a longitudinal study of 46 consecutive children (32 term, 14 preterm) with bilateral optic nerve hypoplasia 32 (69.5\%) had associated neurodevelopmental handicap. Of these, 90\% had structural central nervous system abnormalities on computed tomographic brain scans. Neurodevelopmental handicap occurred in 62.5\% of the term and 86\% of the preterm infants respectively. Term infants had a greater incidence of ventral developmental midline defects and proportionately fewer maternal and/or neonatal complications throughout pregnancy, while encephaloclastic lesions were commoner among the premature infants. An association of optic nerve hypoplasia with the twin transfusion syndrome and prenatal vascular encephalopathies is described.
@article{Burke1991,
abstract = {Abnormalities of the central nervous system are frequently described in optic nerve hypoplasia. In a longitudinal study of 46 consecutive children (32 term, 14 preterm) with bilateral optic nerve hypoplasia 32 (69.5\%) had associated neurodevelopmental handicap. Of these, 90\% had structural central nervous system abnormalities on computed tomographic brain scans. Neurodevelopmental handicap occurred in 62.5\% of the term and 86\% of the preterm infants respectively. Term infants had a greater incidence of ventral developmental midline defects and proportionately fewer maternal and/or neonatal complications throughout pregnancy, while encephaloclastic lesions were commoner among the premature infants. An association of optic nerve hypoplasia with the twin transfusion syndrome and prenatal vascular encephalopathies is described.},
added-at = {2014-07-19T19:13:01.000+0200},
author = {Burke, J. P. and O'Keefe, M. and Bowell, R.},
biburl = {https://www.bibsonomy.org/bibtex/2fa8fdb0d61e8dd806dd9c51f261f0ba7/ar0berts},
groups = {public},
interhash = {e7a1942b74405a88e808cacf79786280},
intrahash = {fa8fdb0d61e8dd806dd9c51f261f0ba7},
journal = {Br J Ophthalmol},
keywords = {Abnormalities, Multiple; Brain; Cerebral Palsy; Child; Child, Preschool; Epilepsy; Evoked Potentials, Visual; Female; Fetofetal Transfusion; Gestational Age; Humans; Infant; Infant, Newbor; Longitudinal Studies; Male; Mental Retardation; Optic Nerve; Pregnancy; Visual Acuity; n},
month = Apr,
number = 4,
pages = {236--239},
pmid = {2021594},
timestamp = {2014-07-19T19:13:01.000+0200},
title = {Optic nerve hypoplasia, encephalopathy, and neurodevelopmental handicap.},
username = {ar0berts},
volume = 75,
year = 1991
}