%0 Journal Article %1 Larson:2012:Bioinformatics:22155872 %A Larson, D E %A Harris, C C %A Chen, K %A Koboldt, D C %A Abbott, T E %A Dooling, D J %A Ley, T J %A Mardis, E R %A Wilson, R K %A Ding, L %D 2012 %J Bioinformatics %K cancer-research exome fulltext gdc pipeline shouldread software variant-calling wxs %N 3 %P 311-317 %R 10.1093/bioinformatics/btr665 %T SomaticSniper: identification of somatic point mutations in whole genome sequencing data %U https://pubmed.ncbi.nlm.nih.gov/22155872/ %V 28 %X The sequencing of tumors and their matched normals is frequently used to study the genetic composition of cancer. Despite this fact, there remains a dearth of available software tools designed to compare sequences in pairs of samples and identify sites that are likely to be unique to one sample.In this article, we describe the mathematical basis of our SomaticSniper software for comparing tumor and normal pairs. We estimate its sensitivity and precision, and present several common sources of error resulting in miscalls.Binaries are freely available for download at http://gmt.genome.wustl.edu/somatic-sniper/current/, implemented in C and supported on Linux and Mac OS X.delarson@wustl.edu; lding@wustl.eduSupplementary data are available at Bioinformatics online.

@article{Larson:2012:Bioinformatics:22155872, abstract = {The sequencing of tumors and their matched normals is frequently used to study the genetic composition of cancer. Despite this fact, there remains a dearth of available software tools designed to compare sequences in pairs of samples and identify sites that are likely to be unique to one sample.In this article, we describe the mathematical basis of our SomaticSniper software for comparing tumor and normal pairs. We estimate its sensitivity and precision, and present several common sources of error resulting in miscalls.Binaries are freely available for download at http://gmt.genome.wustl.edu/somatic-sniper/current/, implemented in C and supported on Linux and Mac OS X.delarson@wustl.edu; lding@wustl.eduSupplementary data are available at Bioinformatics online.}, added-at = {2020-08-21T09:28:30.000+0200}, author = {Larson, D E and Harris, C C and Chen, K and Koboldt, D C and Abbott, T E and Dooling, D J and Ley, T J and Mardis, E R and Wilson, R K and Ding, L}, biburl = {https://www.bibsonomy.org/bibtex/2fba4081d904aeb598f91e9f09f30ff60/marcsaric}, description = {SomaticSniper: identification of somatic point mutations in whole genome sequencing data - PubMed}, doi = {10.1093/bioinformatics/btr665}, interhash = {6a7920e4c6e131214a3badaf86b95c7d}, intrahash = {fba4081d904aeb598f91e9f09f30ff60}, journal = {Bioinformatics}, keywords = {cancer-research exome fulltext gdc pipeline shouldread software variant-calling wxs}, month = feb, number = 3, pages = {311-317}, pmid = {22155872}, timestamp = {2020-08-21T09:28:30.000+0200}, title = {SomaticSniper: identification of somatic point mutations in whole genome sequencing data}, url = {https://pubmed.ncbi.nlm.nih.gov/22155872/}, volume = 28, year = 2012 }