Disruption of the zinc finger gene GLI3 has been shown to be the cause of Greig cephalopolysyndactyly syndrome (GCPS), at least in some GCPS translocation patients. To characterize this genomic region on human chromosome 7p13, we have isolated a YAC contig of more than 1000 kb including the GLI3 gene. In this contig the gene itself spans at least 200-250 kb. A CpG island is located in the vicinity of the 5' region of the known GLI3 cDNA, implying a potential promoter region.
%0 Journal Article
%1 Vortkamp.1994
%A Vortkamp, A.
%A Gessler, M.
%A Le Paslier, D.
%A Elaswarapu, R.
%A Smith, S.
%A Grzeschik, K. H.
%D 1994
%J Genomics
%K (Genetics) *Nerve *Repressor *Transcription *Xenopus 7 Abnormalities;Multiple/*genetics Base Bones/abnormalities Chromosome Chromosomes;Artificial;Yeast Chromosomes;Human;Pair Cloning;Molecular DNA DNA-Binding Data Facial Factors Fingers/*genetics Humans Kruppel-Like Mapping Molecular Polydactyly/*genetics Primers/genetics Promoter Proteins Proteins/*genetics Regions Sequence Skull/*abnormalities Syndactyly/*genetics Syndrome Tissue Transcription Zinc
%N 3
%P 563--568
%T Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region
%V 22
%X Disruption of the zinc finger gene GLI3 has been shown to be the cause of Greig cephalopolysyndactyly syndrome (GCPS), at least in some GCPS translocation patients. To characterize this genomic region on human chromosome 7p13, we have isolated a YAC contig of more than 1000 kb including the GLI3 gene. In this contig the gene itself spans at least 200-250 kb. A CpG island is located in the vicinity of the 5' region of the known GLI3 cDNA, implying a potential promoter region.
@article{Vortkamp.1994,
abstract = {Disruption of the zinc finger gene GLI3 has been shown to be the cause of Greig cephalopolysyndactyly syndrome (GCPS), at least in some GCPS translocation patients. To characterize this genomic region on human chromosome 7p13, we have isolated a YAC contig of more than 1000 kb including the GLI3 gene. In this contig the gene itself spans at least 200-250 kb. A CpG island is located in the vicinity of the 5' region of the known GLI3 cDNA, implying a potential promoter region.},
added-at = {2013-01-29T13:47:26.000+0100},
author = {Vortkamp, A. and Gessler, M. and Le Paslier, D. and Elaswarapu, R. and Smith, S. and Grzeschik, K. H.},
biburl = {https://www.bibsonomy.org/bibtex/2fd9f9d1461081c0406c754b94715f3ca/ebch},
interhash = {2bcf99d02e0c5145617b8d508df12ac8},
intrahash = {fd9f9d1461081c0406c754b94715f3ca},
journal = {Genomics},
keywords = {(Genetics) *Nerve *Repressor *Transcription *Xenopus 7 Abnormalities;Multiple/*genetics Base Bones/abnormalities Chromosome Chromosomes;Artificial;Yeast Chromosomes;Human;Pair Cloning;Molecular DNA DNA-Binding Data Facial Factors Fingers/*genetics Humans Kruppel-Like Mapping Molecular Polydactyly/*genetics Primers/genetics Promoter Proteins Proteins/*genetics Regions Sequence Skull/*abnormalities Syndactyly/*genetics Syndrome Tissue Transcription Zinc},
number = 3,
pages = {563--568},
timestamp = {2013-01-29T13:47:35.000+0100},
title = {Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region},
volume = 22,
year = 1994
}