%0 Journal Article %1 Wichmann.1983 %A Wichmann, Heinz-Erich %A Loeffler, Markus %A Herkenrath, P. %A Gerhardts, M. D. %A Wesselborg, C. %A Wulff, H. %D 1983 %J Klinische Wochenschrift %K IMISE-Publikationen %N 19 %P 935–940 %T Mathematische Modelle in der Hämatologie %V 61 %X The use of mathematical models in haematology is shown by some examples concerning stem cell kinetics, erythropoiesis and thrombopoiesis. At first, model assumptions are formulated which include the biological knowledge and some regulatory hypotheses. Then, the reaction of the model on stimulation and suppression is calculated. Finally, by comparison with experimental or clinical data one can evaluate how far the model assumptions are sufficient to understand the measurements. Thus one can exclude wrong hypotheses and identify the important regulatory influences.

@article{Wichmann.1983, abstract = {The use of mathematical models in haematology is shown by some examples concerning stem cell kinetics, erythropoiesis and thrombopoiesis. At first, model assumptions are formulated which include the biological knowledge and some regulatory hypotheses. Then, the reaction of the model on stimulation and suppression is calculated. Finally, by comparison with experimental or clinical data one can evaluate how far the model assumptions are sufficient to understand the measurements. Thus one can exclude wrong hypotheses and identify the important regulatory influences.}, added-at = {2014-10-17T12:55:47.000+0200}, author = {Wichmann, Heinz-Erich and Loeffler, Markus and Herkenrath, P. and Gerhardts, M. D. and Wesselborg, C. and Wulff, H.}, biburl = {https://www.bibsonomy.org/bibtex/237fe005ce89832d6d318b5566826cf2b/drtester}, interhash = {30b322e29874db5cb888db75a7342ce8}, intrahash = {37fe005ce89832d6d318b5566826cf2b}, journal = {Klinische Wochenschrift}, keywords = {IMISE-Publikationen}, number = 19, pages = {935–940}, timestamp = {2014-12-03T00:00:39.000+0100}, title = {Mathematische Modelle in der Hämatologie}, volume = 61, year = 1983 }