%0 Journal Article %1 sims2011nodisease. %A Sims, R %A Dwyer, S %A Harold, D %A Gerrish, A %A Hollingworth, P %A Chapman, J %A Jones, N %A Abraham, R %A Ivanov, D %A Pahwa, JS %A Moskvina, V %A Dowzell, K %A Thomas, C %A Stretton, A %A Lovestone, S %A Powell, J %A Proitsi, P %A Lupton, MK %A Brayne, C %A Rubinsztein, DC %A Gill, M %A Lawlor, B %A Lynch, A %A Morgan, K %A Brown, KS %A Passmore, PA %A Craig, D %A McGuiness, B %A Todd, S %A Johnston, JA %A Holmes, C %A Mann, D %A Smith, AD %A Love, S %A Kehoe, PG %A Hardy, J %A Mead, S %A Fox, N %A Rossor, M %A Collinge, J %A Livingston, G %A Bass, NJ %A Gurling, H %A McQuillin, A %A Jones, L %A Holmans, PA %A O'Donovan, M %A Owen, MJ %A Williams, J %C MRC Centre for Neuropyschiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park. simsrc@cardiff.ac.uk %D 2011 %J Am J Med Genet B Neuropsychiatr Genet %K imported %N 7 %P 764--771 %R 10.1002/ajmg.b.31216 %T No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. %U http://www.ncbi.nlm.nih.gov/pubmed/21812096 %V 156B %X We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

@article{sims2011nodisease., abstract = {We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.}, added-at = {2013-08-12T12:53:15.000+0200}, address = {MRC Centre for Neuropyschiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park. simsrc@cardiff.ac.uk}, author = {Sims, R and Dwyer, S and Harold, D and Gerrish, A and Hollingworth, P and Chapman, J and Jones, N and Abraham, R and Ivanov, D and Pahwa, JS and Moskvina, V and Dowzell, K and Thomas, C and Stretton, A and Lovestone, S and Powell, J and Proitsi, P and Lupton, MK and Brayne, C and Rubinsztein, DC and Gill, M and Lawlor, B and Lynch, A and Morgan, K and Brown, KS and Passmore, PA and Craig, D and McGuiness, B and Todd, S and Johnston, JA and Holmes, C and Mann, D and Smith, AD and Love, S and Kehoe, PG and Hardy, J and Mead, S and Fox, N and Rossor, M and Collinge, J and Livingston, G and Bass, NJ and Gurling, H and McQuillin, A and Jones, L and Holmans, PA and O'Donovan, M and Owen, MJ and Williams, J}, biburl = {https://www.bibsonomy.org/bibtex/2d63edf13cb1b98338b4688ffcaa4e17f/sokratesagogo}, doi = {10.1002/ajmg.b.31216}, eissn = {1552-485X}, interhash = {3180fd8e8085a72f843bb8d9e7d6767c}, intrahash = {d63edf13cb1b98338b4688ffcaa4e17f}, journal = {Am J Med Genet B Neuropsychiatr Genet}, keyword = {Aged}, keywords = {imported}, language = {eng}, month = Dec, number = 7, organization = {United States}, pages = {764--771}, timestamp = {2013-08-12T12:53:29.000+0200}, title = {No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21812096}, volume = {156B}, year = 2011 }