%0 Journal Article %1 gibiansky:2010rj %A Gibiansky, Maxsim L %A Conrad, Jacinta C %A Jin, Fan %A Gordon, Vernita D %A Motto, Dominick a %A Mathewson, Margie a %A Stopka, Wiktor G %A Zelasko, Daria C %A Shrout, Joshua D %A Wong, Gerard C L %D 2010 %J Science (New York, N.Y.) %K Adhesion,Biofilms,Cell Algorithms,Bacterial Bacterial,Fimbriae, Bacterial: Division,Databases, Factual,Fimbriae, Pictures Topic,Movement,Mutation,Pseudomonas aeruginosa,Pseudomonas aeruginosa: as genetics,Pseudomonas physiology,Microscopy,Motion physiology,Pseudomonas ultrastructure %N 6001 %P 197 %R 10.1126/science.1194238 %T Bacteria use type IV pili to walk upright and detach from surfaces. %U http://www.ncbi.nlm.nih.gov/pubmed/20929769 %V 330 %X Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases of bacterial behavior, we identified fundamental type IV pili-driven mechanisms for Pseudomonas aeruginosa surface motility involved in distinct foraging strategies. Bacteria stood upright and ``walked'' with trajectories optimized for two-dimensional surface exploration. Vertical orientation facilitated surface detachment and could influence biofilm morphology.

@article{gibiansky:2010rj, abstract = {Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases of bacterial behavior, we identified fundamental type IV pili-driven mechanisms for Pseudomonas aeruginosa surface motility involved in distinct foraging strategies. Bacteria stood upright and ``walked'' with trajectories optimized for two-dimensional surface exploration. Vertical orientation facilitated surface detachment and could influence biofilm morphology.}, added-at = {2013-11-08T00:45:00.000+0100}, author = {Gibiansky, Maxsim L and Conrad, Jacinta C and Jin, Fan and Gordon, Vernita D and Motto, Dominick a and Mathewson, Margie a and Stopka, Wiktor G and Zelasko, Daria C and Shrout, Joshua D and Wong, Gerard C L}, bdsk-file-1 = {YnBsaXN0MDDUAQIDBAUGJCVYJHZlcnNpb25YJG9iamVjdHNZJGFyY2hpdmVyVCR0b3ASAAGGoKgHCBMUFRYaIVUkbnVsbNMJCgsMDxJXTlMua2V5c1pOUy5vYmplY3RzViRjbGFzc6INDoACgAOiEBGABIAFgAdccmVsYXRpdmVQYXRoWWFsaWFzRGF0YV8QFEdpYmlhbnNreS0yMDEwYWEucGRm0hcLGBlXTlMuZGF0YU8RAZgAAAAAAZgAAgAABVNvbmljAAAAAAAAAAAAAAAAAAAAAAAAAAAAAM3ORKBIKwAAAAUtJxRHaWJpYW5za3ktMjAxMGFhLnBkZgAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAACJd7ykxI7gAAAAAAAAAAAAEAAgAACSAAAAAAAAAAAAAAAAAAAAAKUmVmZXJlbmNlcwAQAAgAAM3OivAAAAARAAgAAMpMjz4AAAABABAABS0nAAUsGwAFA1IAAhA3AAIAPlNvbmljOlVzZXJzOgBhbmRyZXM6AERyb3Bib3g6AFJlZmVyZW5jZXM6AEdpYmlhbnNreS0yMDEwYWEucGRmAA4AKgAUAEcAaQBiAGkAYQBuAHMAawB5AC0AMgAwADEAMABhAGEALgBwAGQAZgAPAAwABQBTAG8AbgBpAGMAEgA0VXNlcnMvYW5kcmVzL0Ryb3Bib3gvUmVmZXJlbmNlcy9HaWJpYW5za3ktMjAxMGFhLnBkZgATAAEvAAAVAAIADf//AACABtIbHB0eWiRjbGFzc25hbWVYJGNsYXNzZXNdTlNNdXRhYmxlRGF0YaMdHyBWTlNEYXRhWE5TT2JqZWN00hscIiNcTlNEaWN0aW9uYXJ5oiIgXxAPTlNLZXllZEFyY2hpdmVy0SYnVHJvb3SAAQAIABEAGgAjAC0AMgA3AEAARgBNAFUAYABnAGoAbABuAHEAcwB1AHcAhACOAKUAqgCyAk4CUAJVAmACaQJ3AnsCggKLApACnQKgArICtQK6AAAAAAAAAgEAAAAAAAAAKAAAAAAAAAAAAAAAAAAAArw=}, bdsk-url-1 = {http://www.ncbi.nlm.nih.gov/pubmed/20929769}, bdsk-url-2 = {http://dx.doi.org/10.1126/science.1194238}, biburl = {https://www.bibsonomy.org/bibtex/2f626d233f22c84dfd0a9d78819c48854/andresgm}, date-modified = {2011-07-22 23:02:13 +0000}, doi = {10.1126/science.1194238}, interhash = {328795cabd8883ba5d20a4b032600aad}, intrahash = {f626d233f22c84dfd0a9d78819c48854}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {Adhesion,Biofilms,Cell Algorithms,Bacterial Bacterial,Fimbriae, Bacterial: Division,Databases, Factual,Fimbriae, Pictures Topic,Movement,Mutation,Pseudomonas aeruginosa,Pseudomonas aeruginosa: as genetics,Pseudomonas physiology,Microscopy,Motion physiology,Pseudomonas ultrastructure}, month = oct, number = 6001, pages = 197, pmid = {20929769}, timestamp = {2013-11-08T00:45:00.000+0100}, title = {Bacteria use type IV pili to walk upright and detach from surfaces.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20929769}, volume = 330, year = 2010 }