%0 Journal Article %1 citeulike:9841048 %A Lavie, Carl J. %A Lee, John H. %A Milani, Richard V. %D 2011 %J J Am Coll Cardiol %K cvd, vitamind %N 15 %P 1547--1556 %R 10.1016/j.jacc.2011.07.008 %T Vitamin D and Cardiovascular Disease: Will It Live Up to its Hype? %U http://dx.doi.org/10.1016/j.jacc.2011.07.008 %V 58 %X Substantial evidence suggests that a large portion of the population have suboptimal levels of vitamin D, which may adversely affect the cardiovascular (CV) system, including increasing levels of parathyroid hormone, activating the renin-angiotensin-aldosterone system, and increasing insulin resistance, thus leading to hypertension and left ventricular hypertrophy, metabolic syndrome/diabetes mellitus, systemic inflammation, and increased risk of atherosclerosis and CV disease events. We review the evidence that vitamin D deficiency is associated with incident CV disease events, as well as evidence that vitamin D supplementation is associated with reduction in CV diseases. Although the current evidence has created substantial hype, randomized controlled trials are needed to determine whether routine vitamin D assessment and supplementation will improve CV outcomes.

@article{citeulike:9841048, abstract = {{Substantial evidence suggests that a large portion of the population have suboptimal levels of vitamin D, which may adversely affect the cardiovascular (CV) system, including increasing levels of parathyroid hormone, activating the renin-angiotensin-aldosterone system, and increasing insulin resistance, thus leading to hypertension and left ventricular hypertrophy, metabolic syndrome/diabetes mellitus, systemic inflammation, and increased risk of atherosclerosis and CV disease events. We review the evidence that vitamin D deficiency is associated with incident CV disease events, as well as evidence that vitamin D supplementation is associated with reduction in CV diseases. Although the current evidence has created substantial hype, randomized controlled trials are needed to determine whether routine vitamin D assessment and supplementation will improve CV outcomes.}}, added-at = {2011-11-04T06:39:59.000+0100}, author = {Lavie, Carl J. and Lee, John H. and Milani, Richard V.}, biburl = {https://www.bibsonomy.org/bibtex/250ec50ba32e607d4c1689b3dd5c9cffe/alimuzaffar}, citeulike-article-id = {9841048}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jacc.2011.07.008}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0735109711026489}, citeulike-linkout-2 = {http://content.onlinejacc.org/cgi/content/abstract/58/15/1547}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/21958881}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=21958881}, day = 4, doi = {10.1016/j.jacc.2011.07.008}, interhash = {330269187111f01688425b78cb6f633a}, intrahash = {50ec50ba32e607d4c1689b3dd5c9cffe}, issn = {07351097}, journal = {J Am Coll Cardiol}, keywords = {cvd, vitamind}, month = oct, number = 15, pages = {1547--1556}, pmid = {21958881}, posted-at = {2011-11-02 11:52:30}, priority = {2}, timestamp = {2011-11-04T06:39:59.000+0100}, title = {{Vitamin D and Cardiovascular Disease: Will It Live Up to its Hype?}}, url = {http://dx.doi.org/10.1016/j.jacc.2011.07.008}, volume = 58, year = 2011 }