Zusammenfassung
We expanded the meningococcal serogroup A, C, Y, and W-135 multiplex immunoassay (MIA) to simultaneously detect immunoglobulin type G antibodies directed toward Haemophilus influenzae type b polysaccharide (HibPS). The monoplex HibPS assay was compared to a HibPS-specific competitive enzyme-linked immunosorbent assay and showed a good correlation (R=0.96). Furthermore, no cross-reactivity between HibPS and the four meningococcal serogroups was detected. This pentaplex meningococcal Hib MIA is a useful tool to investigate serological responses toward different childhood PS vaccines.
- a,
- and
- antibodies,
- antigens,
- b,
- bacterial,
- c,
- cross
- fluorescence,
- g,
- haemophilus
- humans,
- immunoassay,
- immunoglobulin
- influenzae
- meningitidis,
- microspheres,
- neisseria
- polysaccharides,
- reactions,
- sensitivity
- serogroup
- specificity
- type
- w-135,
- y,
Nutzer