Abstract
Pharyngeal colonization by Streptococcus pneumoniae was evaluated in 103 human immunodeficiency virus (HIV)-infected subjects (\textless200 CD4 cells/microL, 57; \textgreater or = 200 CD4 cells/microL, 46) and 39 non-HIV-infected controls who were participants in a vaccine study. At baseline, 7\%, 20\%, and 10\% of subjects in the \textless200 and \textgreater or = 200 CD4 cell groups and in the control group were colonized with S. pneumoniae: Rates at 6 months were 23\%, 22\%, and 0\%, respectively. Of 34 isolates from HIV-infected subjects, 25 were penicillin-resistant and 19 were resistant to \textgreater or = 3 antimicrobials; of 8 isolates from controls, 1 was resistant. Resistance to trimethoprim-sulfamethoxazole was significantly higher among HIV-infected subjects with \textless200 CD4 cells/microL than in those with more CD4 cells. Polymerase chain reaction DNA analysis with BOX primers demonstrated that 12 HIV-infected subjects were persistently colonized with the same S. pneumoniae strain for \textgreater or = 1 month compared with none of the controls. HIV-infected subjects were more likely to be persistent pneumococcal carriers and to carry antibiotic-resistant isolates than were non-HIV-infected subjects.
- adult,
- aged,
- bacterial,
- carrier
- chain
- count,
- drug
- factors,
- humans,
- infections,
- lymphocyte
- male,
- microbial,
- middle
- pharyngitis,
- pharynx,
- pneumoniae
- polymerase
- reaction,
- resistance,
- risk
- state,
- streptococcal
- streptococcus
- {cd4}
- {dna,}
- {hiv}
Users
Please
log in to take part in the discussion (add own reviews or comments).