%0 Journal Article %1 Hansen2004a %A Hansen, B. M?lholm %A Hoff, B. %A Uldall, P. %A Greisen, G. %A Kamper, J. %A Djernes, B. %A Hertel, J. %A Christensen, M. F. %A Andersen, E. %A Lillquist, K. %A Verder, H. %A Peitersen, B. %A Grytter, C. %A Agertoft, L. %A Andersen, E. A. %A Berg, A. %A Krag-Olsen, B. %A Sardeman, H. %A Jonsbo, F. %A J?rgensen, N. F. %A Christensen, N. C. %A Nielsen, F. %A Ebbesen, F. %A Pryds, O. %A Lange, A. %A Group, Danish ETFOL %D 2004 %J Acta Paediatr %K Cerebral Palsy; Cognition Disorders; Cohort Studies; Female; Follow-Up Humans; Infant, Newborn; Premature; Male; Positive-Pressure Respiration; Postpartum Period; Pregnancy; Pregnancy Outcome; Prospective Respiration, Artificial; Respiratory Insufficiency; Risk Factors %N 2 %P 185--189 %T Perinatal risk factors of adverse outcome in very preterm children: a role of initial treatment of respiratory insufficiency? %V 93 %X AIM: To investigate risk factors of adverse outcome in a cohort of very preterm children treated mainly with nasal continuous positive airway pressure (CPAP) during the neonatal course. METHODS: In Denmark, preterm children are treated with nasal CPAP as a first approach to respiratory support. A national prospective study of all infants with a birthweight below 1000 g or a gestational age below 28 wk born in 1994-1995 was initiated to evaluate this approach. Of the 269 surviving children 164 (61\%) were not treated with mechanical ventilation in the neonatal period. A follow-up of the children at 5 y of age was conducted. Data from the neonatal period and the 5-y follow-up were analysed. RESULTS: In multivariate analyses including 250 children, a severely abnormal neonatal brain ultrasound scan was predictive of cerebral palsy (OR = 19.9, CI 95\%: 6.1-64.8) and intellectual disability (OR = 6.2, CI 95\%: 2.3-16.5). A high Clinical Risk Index for Babies (CRIB) score (OR = 2.4, CI 95\%: 1.1-5.5) and chronic lung disease (OR = 2.8, CI 95\%: 1.2-6.9) were predictive of intellectual disability. In univariate analyses mechanical ventilation was associated with cerebral palsy (OR=4.3, CI 95\%: 1.7-10.8) and intellectual disability (OR = 2.2, CI 95\%: 1.2-4.2), but the associations became insignificant in multivariate analyses including chronic lung disease and a severely abnormal ultrasound scan. CONCLUSION: The associations between neonatal risk factors and adverse outcome in our cohort were very similar to those found in other cohorts with another initial treatment of respiratory insufficiency. We found no significant adverse effects of mechanical ventilation beyond what could be explained by associations with chronic lung disease and IVH 3-4/PVL.

@article{Hansen2004a, abstract = {AIM: To investigate risk factors of adverse outcome in a cohort of very preterm children treated mainly with nasal continuous positive airway pressure (CPAP) during the neonatal course. METHODS: In Denmark, preterm children are treated with nasal CPAP as a first approach to respiratory support. A national prospective study of all infants with a birthweight below 1000 g or a gestational age below 28 wk born in 1994-1995 was initiated to evaluate this approach. Of the 269 surviving children 164 (61\%) were not treated with mechanical ventilation in the neonatal period. A follow-up of the children at 5 y of age was conducted. Data from the neonatal period and the 5-y follow-up were analysed. RESULTS: In multivariate analyses including 250 children, a severely abnormal neonatal brain ultrasound scan was predictive of cerebral palsy (OR = 19.9, CI 95\%: 6.1-64.8) and intellectual disability (OR = 6.2, CI 95\%: 2.3-16.5). A high Clinical Risk Index for Babies (CRIB) score (OR = 2.4, CI 95\%: 1.1-5.5) and chronic lung disease (OR = 2.8, CI 95\%: 1.2-6.9) were predictive of intellectual disability. In univariate analyses mechanical ventilation was associated with cerebral palsy (OR=4.3, CI 95\%: 1.7-10.8) and intellectual disability (OR = 2.2, CI 95\%: 1.2-4.2), but the associations became insignificant in multivariate analyses including chronic lung disease and a severely abnormal ultrasound scan. CONCLUSION: The associations between neonatal risk factors and adverse outcome in our cohort were very similar to those found in other cohorts with another initial treatment of respiratory insufficiency. We found no significant adverse effects of mechanical ventilation beyond what could be explained by associations with chronic lung disease and IVH 3-4/PVL.}, added-at = {2014-07-19T20:22:59.000+0200}, author = {Hansen, B. M?lholm and Hoff, B. and Uldall, P. and Greisen, G. and Kamper, J. and Djernes, B. and Hertel, J. and Christensen, M. F. and Andersen, E. and Lillquist, K. and Verder, H. and Peitersen, B. and Grytter, C. and Agertoft, L. and Andersen, E. A. and Berg, A. and Krag-Olsen, B. and Sardeman, H. and Jonsbo, F. and J?rgensen, N. F. and Christensen, N. C. and Nielsen, F. and Ebbesen, F. and Pryds, O. and Lange, A. and Group, Danish ETFOL}, biburl = {https://www.bibsonomy.org/bibtex/224ad8612d6b49e9a4971fb0d2d6917bd/ar0berts}, groups = {public}, interhash = {429a292d6884ab7f032bf7161ef7fa72}, intrahash = {24ad8612d6b49e9a4971fb0d2d6917bd}, journal = {Acta Paediatr}, keywords = {Cerebral Palsy; Cognition Disorders; Cohort Studies; Female; Follow-Up Humans; Infant, Newborn; Premature; Male; Positive-Pressure Respiration; Postpartum Period; Pregnancy; Pregnancy Outcome; Prospective Respiration, Artificial; Respiratory Insufficiency; Risk Factors}, month = Feb, number = 2, pages = {185--189}, pmid = {15046271}, timestamp = {2014-07-19T20:22:59.000+0200}, title = {Perinatal risk factors of adverse outcome in very preterm children: a role of initial treatment of respiratory insufficiency?}, username = {ar0berts}, volume = 93, year = 2004 }