%0 Journal Article %1 Ferrara.2003 %A Ferrara, N. %A Gerber, H. P. %A LeCouter, J. %D 2003 %J Nat.Med. %K A Animals Clinical Dna Endothelial Endothelium Factor Factors Growth Humans Intercellular Isoforms Lymphokines Neovascularization Oxygen Pathologic Peptides Physiologic Protein Proteins Receptors Signal Signaling Substances Topic Transduction Trials Tyrosine Vascular and as cytology genetics metabolism physiology protein therapeutic use %N 6 %P 669-676 %T The biology of VEGF and its receptors %U PM:12778165 %V 9 %X Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF RTK signaling. Currently, several VEGF inhibitors are undergoing clinical testing in several malignancies. VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration

@article{Ferrara.2003, abstract = {Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF RTK signaling. Currently, several VEGF inhibitors are undergoing clinical testing in several malignancies. VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Ferrara, N. and Gerber, H. P. and LeCouter, J.}, biburl = {https://www.bibsonomy.org/bibtex/25a60e8a9367558692f26250f3a3a3228/kanefendt}, interhash = {4466555511990374842e3671cbfdfef1}, intrahash = {5a60e8a9367558692f26250f3a3a3228}, journal = {Nat.Med.}, keywords = {A Animals Clinical Dna Endothelial Endothelium Factor Factors Growth Humans Intercellular Isoforms Lymphokines Neovascularization Oxygen Pathologic Peptides Physiologic Protein Proteins Receptors Signal Signaling Substances Topic Transduction Trials Tyrosine Vascular and as cytology genetics metabolism physiology protein therapeutic use}, number = 6, pages = {669-676}, timestamp = {2010-02-05T11:28:40.000+0100}, title = {The biology of VEGF and its receptors}, url = {PM:12778165}, volume = 9, year = 2003 }