%0 Journal Article %1 Fieuws2004 %A Fieuws, Steffen %A Verbeke, Geert %D 2004 %J Statistics in medicine %K Adolescent Adult Aged Biological HearingLoss Humans LongitudinalStudies Male MiddleAged Models MultivariateAnalysis Statistical %N 20 %P 3093-104 %R 10.1002/sim.1885 %T Joint modelling of multivariate longitudinal profiles: pitfalls of the random-effects approach. %U http://www.ncbi.nlm.nih.gov/pubmed/15449333 %V 23 %X Due to its flexibility, the random-effects approach for the joint modelling of multivariate longitudinal profiles received a lot of attention in recent publications. In this approach different mixed models are joined by specifying a common distribution for their random-effects. Parameter estimates of this common distribution can then be used to evaluate the relation between the different responses. Using bivariate longitudinal measurements on pure-tone hearing thresholds, it will be shown that such a random-effects approach can yield misleading results for evaluating this relationship. %@ 0277-6715

@article{Fieuws2004, abstract = {Due to its flexibility, the random-effects approach for the joint modelling of multivariate longitudinal profiles received a lot of attention in recent publications. In this approach different mixed models are joined by specifying a common distribution for their random-effects. Parameter estimates of this common distribution can then be used to evaluate the relation between the different responses. Using bivariate longitudinal measurements on pure-tone hearing thresholds, it will be shown that such a random-effects approach can yield misleading results for evaluating this relationship.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Fieuws, Steffen and Verbeke, Geert}, biburl = {https://www.bibsonomy.org/bibtex/2b2444c34b578a8fb654fa4834364e26d/jepcastel}, city = {Biostatistical Centre, Katholieke Universiteit Leuven, Kapucijnenvoer 35, B-3000 Leuven, Belgium. steffen.fieuws@med.kuleuven.ac.be}, doi = {10.1002/sim.1885}, interhash = {4aaed0afac392164149f5f022743ca5e}, intrahash = {b2444c34b578a8fb654fa4834364e26d}, isbn = {0277-6715}, issn = {0277-6715}, journal = {Statistics in medicine}, keywords = {Adolescent Adult Aged Biological HearingLoss Humans LongitudinalStudies Male MiddleAged Models MultivariateAnalysis Statistical}, month = {10}, note = {4302<m:linebreak></m:linebreak>PUBM: Print; CI: Copyright 2004; JID: 8215016; ppublish;<m:linebreak></m:linebreak>Mixed models}, number = 20, pages = {3093-104}, pmid = {15449333}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Joint modelling of multivariate longitudinal profiles: pitfalls of the random-effects approach.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/15449333}, volume = 23, year = 2004 }