%0 Journal Article %1 schaumburg_population_2012 %A Schaumburg, Frieder %A Köck, Robin %A Mellmann, Alexander %A Richter, Laura %A Hasenberg, Felicitas %A Kriegeskorte, André %A Friedrich, Alexander W %A Gatermann, Sören %A Peters, Georg %A von Eiff, Christof %A Becker, Karsten %A study group, %D 2012 %J Journal of clinical microbiology %K 80_and_over Adult Aged Bacterial_Proteins Bacterial_Toxins Carrier_State Exotoxins Female Genetic_Variation Genotype Germany Humans Leukocidins Male Methicillin-Resistant_Staphylococcus_aureus Middle_Aged Molecular_Typing Molecular_epidemiology Prospective_Studies Staphylococcal_Infections Staphylococcal_Protein_A infection_control molecular_epidemiology %N 10 %P 3186--3192 %R 10.1128/JCM.01174-12 %T Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period %V 50 %X Methicillin-resistant Staphylococcus aureus (MRSA) originated from the health care setting but is now emerging in communities without health care contact (CA-MRSA) or in livestock (LA-MRSA). The impact on the whole MRSA population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 MRSA isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of mecA or its homologue mecA(LGA251). The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) MRSA isolates were analyzed; one isolate from each sampling period harbored mecA(LGA251). LA-MRSA increased significantly (odds ratio OR = 22.67, 95\% confidence interval CI = 8.51 to 85.49, P \textless 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive CA-MRSA rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7\%, OR = 2.80, 95\% CI = 1.54 to 5.34, P \textless 0.0005). The emerging MRSA clones changed the MRSA population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of MRSA sources create a need for revision of guidelines for MRSA infection control and treatment.

@article{schaumburg_population_2012, abstract = {Methicillin-resistant Staphylococcus aureus ({MRSA)} originated from the health care setting but is now emerging in communities without health care contact ({CA-MRSA)} or in livestock ({LA-MRSA).} The impact on the whole {MRSA} population was assessed in a German prospective multicenter study. Thirty-three laboratories consecutively collected up to 50 {MRSA} isolates from infection or carriage during two sampling periods in 2004 to 2005 and 2010 to 2011. Patient-related data were collected using a standardized questionnaire. Methicillin resistance was confirmed by the detection of {mecA} or its homologue {mecA(LGA251).} The spa type and major virulence factors were analyzed for each isolate. In total, 1,604 (2004 to 2005) and 1,603 (2010 to 2011) {MRSA} isolates were analyzed; one isolate from each sampling period harbored {mecA(LGA251).} {LA-MRSA} increased significantly (odds ratio [{OR]} = 22.67, 95\% confidence interval [{CI]} = 8.51 to 85.49, P {\textless} 0.0005) and spread over Germany, originating from northwestern regions. Panton-Valentine leukocidin-positive {CA-MRSA} rose significantly, particularly in southern Germany, but the proportion in 2010 to 2011 remained low (2.7\%, {OR} = 2.80, 95\% {CI} = 1.54 to 5.34, P {\textless} 0.0005). The emerging {MRSA} clones changed the {MRSA} population in Germany during a 6-year period significantly. The ongoing epidemiological shift and changes of {MRSA} sources create a need for revision of guidelines for {MRSA} infection control and treatment.}, added-at = {2013-10-04T09:46:01.000+0200}, author = {Schaumburg, Frieder and Köck, Robin and Mellmann, Alexander and Richter, Laura and Hasenberg, Felicitas and Kriegeskorte, André and Friedrich, Alexander W and Gatermann, Sören and Peters, Georg and von Eiff, Christof and Becker, Karsten and {study group}}, biburl = {https://www.bibsonomy.org/bibtex/2302ab71aae3343dec094ed31e4df549a/ag_vogel}, doi = {10.1128/JCM.01174-12}, interhash = {4e2c436af75df50c5cac64624c355582}, intrahash = {302ab71aae3343dec094ed31e4df549a}, issn = {1098-{660X}}, journal = {Journal of clinical microbiology}, keywords = {80_and_over Adult Aged Bacterial_Proteins Bacterial_Toxins Carrier_State Exotoxins Female Genetic_Variation Genotype Germany Humans Leukocidins Male Methicillin-Resistant_Staphylococcus_aureus Middle_Aged Molecular_Typing Molecular_epidemiology Prospective_Studies Staphylococcal_Infections Staphylococcal_Protein_A infection_control molecular_epidemiology}, language = {eng}, month = oct, note = {{PMID:} 22814464}, number = 10, pages = {3186--3192}, timestamp = {2013-10-04T09:46:01.000+0200}, title = {Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period}, volume = 50, year = 2012 }