Article,

Marginal Structural Models: unbiased estimation for longitudinal studies.

, and .
International journal of public health, 56 (1): 117-9 (February 2011)6250<m:linebreak></m:linebreak>GR: Canadian Institutes of Health Research/Canada; JID: 101304551; 2010/05/07 received; 2010/09/12 accepted; 2010/08/01 revised; 2010/10/08 aheadofprint; ppublish;<m:linebreak></m:linebreak>Propensity score; Marginal structural models; Introductori.
DOI: 10.1007/s00038-010-0198-4

Abstract

INTRODUCTION: In this article, we introduce Marginal Structural Models, which yield unbiased estimates of causal effects of exposures in the presence of time-varying confounding variables that also act as mediators. OBJECTIVES: We describe estimation via inverse probability weighting; estimation may also be accomplished by g-computation (Robins in Latent Variable Modeling and Applications to Causality, Springer, New York, pp 69-117, 1997; van der Wal et al. in Stat Med 28:2325-2337, 2009) or targeted maximum likelihood (Rosenblum and van der Laan in Int J Biostat 6, 2010). CONCLUSIONS: When both time-varying confounding and mediation are present in a longitudinal setting data, Marginal Structural Models are a useful tool that provides unbiased estimates.

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