%0 Journal Article %1 King2003a %A King, Wilson %A Levin, Ronald %A Schmidt, Rosemary %A Oestreich, Alan %A Heubi, James E %D 2003 %J Dev Med Child Neurol %K Absorptiometry, Photon; Adolescent; Adult; Anticonvulsants; Bone Density; Diseases, Metabolic; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Female; Fractures, Bone; Hospitals, Pediatric; Humans; Lumbar Vertebrae; Mal; Middle Aged; Muscle Spasticity; Ohio; Osteoporosis; Prevalence; Quadriplegia; Risk Factors; e %N 1 %P 12--16 %T Prevalence of reduced bone mass in children and adults with spastic quadriplegia. %V 45 %X This study was designed to test the hypothesis that non-ambulatory patients with spastic quadriplegia will have reduced bone mass which worsens with increasing age. Forty-eight patients (age 5 to 48 years, median age 15 years; 19 females and 29 males) were studied. Anticonvulsants were used in 29 patients (60.4\%). Lumbar spine bone mineral density (LS-BMD) was markedly reduced compared with age-and sex-matched control individuals with a z score of -2.37 +/- 0.21. Twenty-eight (58\%) had z scores of less than -2. A history of documented previous fracture was present in 19 patients (39\%). Patients with a history of fracture had significantly lower (p = 0.05) LS-BMD z scores (-2.81 +/- 0.29) compared with those without a history of fracture (-2.11 +/- 0.26). Mean serum 25-OH vitamin D was 29.6 +/- 1.9ng/mL (normal 9 to 37.6ng/mL) with three patients having serum 25-OH vitamin D levels less than 15ng/mL. These findings indicate that BMD is markedly reduced in non-ambulatory children and adults with neuromuscular disease. Reductions in bone mass put them at greater risk for non-traumatic fractures.

@article{King2003a, abstract = {This study was designed to test the hypothesis that non-ambulatory patients with spastic quadriplegia will have reduced bone mass which worsens with increasing age. Forty-eight patients (age 5 to 48 years, median age 15 years; 19 females and 29 males) were studied. Anticonvulsants were used in 29 patients (60.4\%). Lumbar spine bone mineral density (LS-BMD) was markedly reduced compared with age-and sex-matched control individuals with a z score of -2.37 +/- 0.21. Twenty-eight (58\%) had z scores of less than -2. A history of documented previous fracture was present in 19 patients (39\%). Patients with a history of fracture had significantly lower (p = 0.05) LS-BMD z scores (-2.81 +/- 0.29) compared with those without a history of fracture (-2.11 +/- 0.26). Mean serum 25-OH vitamin D was 29.6 +/- 1.9ng/mL (normal 9 to 37.6ng/mL) with three patients having serum 25-OH vitamin D levels less than 15ng/mL. These findings indicate that BMD is markedly reduced in non-ambulatory children and adults with neuromuscular disease. Reductions in bone mass put them at greater risk for non-traumatic fractures.}, added-at = {2014-07-19T20:37:54.000+0200}, author = {King, Wilson and Levin, Ronald and Schmidt, Rosemary and Oestreich, Alan and Heubi, James E}, biburl = {https://www.bibsonomy.org/bibtex/289a649a86f35e46cd4af72dc9f6c275d/ar0berts}, groups = {public}, interhash = {507df63446d0850f40be9333034d204a}, intrahash = {89a649a86f35e46cd4af72dc9f6c275d}, journal = {Dev Med Child Neurol}, keywords = {Absorptiometry, Photon; Adolescent; Adult; Anticonvulsants; Bone Density; Diseases, Metabolic; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Female; Fractures, Bone; Hospitals, Pediatric; Humans; Lumbar Vertebrae; Mal; Middle Aged; Muscle Spasticity; Ohio; Osteoporosis; Prevalence; Quadriplegia; Risk Factors; e}, month = Jan, number = 1, pages = {12--16}, pmid = {12549750}, timestamp = {2014-07-19T20:37:54.000+0200}, title = {Prevalence of reduced bone mass in children and adults with spastic quadriplegia.}, username = {ar0berts}, volume = 45, year = 2003 }