%0 Journal Article %1 Manning1997 %A Manning, F. A. %A Bondagji, N. %A Harman, C. R. %A Casiro, O. %A Menticoglou, S. %A Morrison, I. %D 1997 %J J Gynecol Obstet Biol Reprod (Paris) %K Cerebral Palsy; Female; Fetal Monitoring; Humans; Infant, Newborn; Manitoba; Medical Audit; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Reproducibility Results; Risk Factors %N 7 %P 720--729 %T Fetal assessment based on the fetal biophysical profile score: relationship of last BPS result to subsequent cerebral palsy. %V 26 %X OBJECTIVE: The prime intent of this study was to determine the relationship if any between the last fetal biophysical profile score and the risk of cerebral palsy at age 3 years. The secondary objective was to examine the clinical characteristics of infants with cerebral palsy whose obstetric management included serial fetal biophysical profile scores. STUDY DESIGN: The incidence of a high risk pregnant population whose antenatal assessment was by serial fetal biophysical profile scoring was determined by cross-referencing two discrete data bases. The completeness and reliability of the data bases was confirmed by secondary audit. Obstetrical, neonatal and post-natal clinical records of index cases of cerebral palsy were subsequently reviewed, categorized and analyzed. RESULTS: Fetal biophysical profile scores (BPS) were recorded in 22,336 high risk pregnancies: 27 patients delivered an infant subsequently identified as having cerebral palsy (rate 1.21 per 1000). The relationship between last BPS result and cerebral palsy was inverse, exponential and highly significant (R2 = 0.987; p < 0.001). Affected infants with a last abnormal BPS result were significantly more likely to exhibit fetal distress (88.8\%), acidosis (77.7\%), and have neonatal seizures (88.8\%). Antenatal asphyxia was the apparent cause of cerebral damage in 29.6\% of cases. CONCLUSION: The last fetal biophysical profile score is a predictor of the risk of cerebral palsy.

@article{Manning1997, abstract = {OBJECTIVE: The prime intent of this study was to determine the relationship if any between the last fetal biophysical profile score and the risk of cerebral palsy at age 3 years. The secondary objective was to examine the clinical characteristics of infants with cerebral palsy whose obstetric management included serial fetal biophysical profile scores. STUDY DESIGN: The incidence of a high risk pregnant population whose antenatal assessment was by serial fetal biophysical profile scoring was determined by cross-referencing two discrete data bases. The completeness and reliability of the data bases was confirmed by secondary audit. Obstetrical, neonatal and post-natal clinical records of index cases of cerebral palsy were subsequently reviewed, categorized and analyzed. RESULTS: Fetal biophysical profile scores (BPS) were recorded in 22,336 high risk pregnancies: 27 patients delivered an infant subsequently identified as having cerebral palsy (rate 1.21 per 1000). The relationship between last BPS result and cerebral palsy was inverse, exponential and highly significant (R2 = 0.987; p < 0.001). Affected infants with a last abnormal BPS result were significantly more likely to exhibit fetal distress (88.8\%), acidosis (77.7\%), and have neonatal seizures (88.8\%). Antenatal asphyxia was the apparent cause of cerebral damage in 29.6\% of cases. CONCLUSION: The last fetal biophysical profile score is a predictor of the risk of cerebral palsy.}, added-at = {2014-07-19T20:45:25.000+0200}, author = {Manning, F. A. and Bondagji, N. and Harman, C. R. and Casiro, O. and Menticoglou, S. and Morrison, I.}, biburl = {https://www.bibsonomy.org/bibtex/2518c56d734e15c6864426efed7f2d0ad/ar0berts}, groups = {public}, interhash = {574396eb996567ef99e711a0b64559cc}, intrahash = {518c56d734e15c6864426efed7f2d0ad}, journal = {J Gynecol Obstet Biol Reprod (Paris)}, keywords = {Cerebral Palsy; Female; Fetal Monitoring; Humans; Infant, Newborn; Manitoba; Medical Audit; Predictive Value of Tests; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Reproducibility Results; Risk Factors}, number = 7, pages = {720--729}, pii = {66999}, pmid = {9436057}, timestamp = {2014-07-19T20:45:25.000+0200}, title = {Fetal assessment based on the fetal biophysical profile score: relationship of last BPS result to subsequent cerebral palsy.}, username = {ar0berts}, volume = 26, year = 1997 }