%0 Journal Article %1 Baker2002 %A Baker, R. %A Jasinski, M. %A Maciag-Tymecka, I. %A Michalowska-Mrozek, J. %A Bonikowski, M. %A Carr, L. %A MacLean, J. %A Lin, J. P. %A Lynch, B. %A Theologis, T. %A Wendorff, J. %A Eunson, P. %A Cosgrove, A. %D 2002 %J Dev Med Child Neurol %K Botulinum Toxin Type A; Cerebral Palsy; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intramuscular; Male; Muscle Spasticity; Muscle, Skeletal; Neurologic Examination; Treatment Outcome; Walking %N 10 %P 666--675 %T Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomized, double-blind, placebo-controlled, dose-ranging study. %V 44 %X This study evaluated the efficacy and safety of three doses of botulinum toxin A (BTX-A; Dysport) in 125 patients (mean age 5.2 years, SD 2; 54\% male)with dynamic equinus spasticity during walking. Participants were randomized to receive Dysport (10, 20, or 30 units/kg) or placebo to the gastrocnemius muscle of both legs. Muscle length was calculated from electrogoniometric measurements and the change in the dynamic component of gastrocnemius shortening at four weeks was prospectively identified as the primary outcome measure. All treatment groups showed statistically significant decreases in dynamic component compared with placebo at 4 weeks. Mean improvement in dynamic component was most pronounced in the 20 units/kg group, being equivalent to an increase in dorsiflexion with the knee extended at 19 degrees, and was still present at 16 weeks. The safety profile of the toxin appears satisfactory.

@article{Baker2002, abstract = {This study evaluated the efficacy and safety of three doses of botulinum toxin A (BTX-A; Dysport) in 125 patients (mean age 5.2 years, SD 2; 54\% male)with dynamic equinus spasticity during walking. Participants were randomized to receive Dysport (10, 20, or 30 units/kg) or placebo to the gastrocnemius muscle of both legs. Muscle length was calculated from electrogoniometric measurements and the change in the dynamic component of gastrocnemius shortening at four weeks was prospectively identified as the primary outcome measure. All treatment groups showed statistically significant decreases in dynamic component compared with placebo at 4 weeks. Mean improvement in dynamic component was most pronounced in the 20 units/kg group, being equivalent to an increase in dorsiflexion with the knee extended at 19 degrees, and was still present at 16 weeks. The safety profile of the toxin appears satisfactory.}, added-at = {2014-07-19T17:52:29.000+0200}, author = {Baker, R. and Jasinski, M. and Maciag-Tymecka, I. and Michalowska-Mrozek, J. and Bonikowski, M. and Carr, L. and MacLean, J. and Lin, J. P. and Lynch, B. and Theologis, T. and Wendorff, J. and Eunson, P. and Cosgrove, A.}, biburl = {https://www.bibsonomy.org/bibtex/228c083840ae07621dd7c0e1b26dbc1fb/ar0berts}, groups = {public}, interhash = {5b49593850c199280afcd901f6a4b023}, intrahash = {28c083840ae07621dd7c0e1b26dbc1fb}, journal = {Dev Med Child Neurol}, keywords = {Botulinum Toxin Type A; Cerebral Palsy; Child; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Injections, Intramuscular; Male; Muscle Spasticity; Muscle, Skeletal; Neurologic Examination; Treatment Outcome; Walking}, month = Oct, number = 10, pages = {666--675}, pmid = {12418791}, timestamp = {2014-07-19T18:00:41.000+0200}, title = {Botulinum toxin treatment of spasticity in diplegic cerebral palsy: a randomized, double-blind, placebo-controlled, dose-ranging study.}, username = {ar0berts}, volume = 44, year = 2002 }