Article,
Bow ties, metabolism and disease
Trends in Biotechnology, 22 (9): 446--450 (September 2004)
DOI: 10.1016/j.tibtech.2004.07.007
Abstract
Highly organized, universal structures underlying biological and technological networks mediate effective trade-offs among efficiency, robustness and evolvability, with predictable fragilities that can be used to understand disease pathogenesis. The aims of this article are to describe the features of one common organizational architecture in biology, the bow tie. Large-scale organizational frameworks such as the bow tie are necessary starting points for higher-resolution modeling of complex biologic processes
