%0 Journal Article %1 simmons_equivalence_2000 %A Simmons, G %A Jones, N %A Calder, L %D 2000 %J The Journal of Antimicrobial Chemotherapy %K Adolescent, Adult, Antibiotics, Antitubercular, Carrier Ceftriaxone, Cephalosporins, Child, Humans, Infant, Infections, Meningococcal Nasopharynx, Neisseria Newborn, Preschool, Rifampin, Serotyping State, meningitidis, %N 6 %P 909--11 %T Equivalence of ceftriaxone and rifampicin in eliminating nasopharyngeal carriage of serogroup B Neisseria meningitidis %U http://www.ncbi.nlm.nih.gov/pubmed/10837450 %V 45 %X The efficacy of ceftriaxone in eliminating nasopharyngeal carriage of Neisseria meningitidis was compared with that of rifampicin during an epidemic of serogroup B meningococcal disease in Auckland, New Zealand. Household contacts of cases had a throat swab taken and were randomized to treatment. Carriers had a repeat swab taken 6 days later to determine efficacy of treatment. Ceftriaxone (98.2\%) was equivalent to rifampicin (97.6\%) in eliminating serogroup B N. meningitidis. It is cheaper than rifampicin and has the advantage of full compliance and fewer contraindications, but its acceptability by patients may limit its use as a first-line prophylactic agent.

@article{simmons_equivalence_2000, abstract = {The efficacy of ceftriaxone in eliminating nasopharyngeal carriage of Neisseria meningitidis was compared with that of rifampicin during an epidemic of serogroup B meningococcal disease in Auckland, New Zealand. Household contacts of cases had a throat swab taken and were randomized to treatment. Carriers had a repeat swab taken 6 days later to determine efficacy of treatment. Ceftriaxone (98.2\%) was equivalent to rifampicin (97.6\%) in eliminating serogroup B N. meningitidis. It is cheaper than rifampicin and has the advantage of full compliance and fewer contraindications, but its acceptability by patients may limit its use as a first-line prophylactic agent.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Simmons, G and Jones, N and Calder, L}, biburl = {https://www.bibsonomy.org/bibtex/2033012ef113f9db2c2e3d6d728ad3e0d/jelias}, interhash = {62acaaed7a56811d8a0a879fe4d25686}, intrahash = {033012ef113f9db2c2e3d6d728ad3e0d}, issn = {0305-7453}, journal = {The Journal of Antimicrobial Chemotherapy}, keywords = {Adolescent, Adult, Antibiotics, Antitubercular, Carrier Ceftriaxone, Cephalosporins, Child, Humans, Infant, Infections, Meningococcal Nasopharynx, Neisseria Newborn, Preschool, Rifampin, Serotyping State, meningitidis,}, month = jun, note = {{PMID:} 10837450}, number = 6, pages = {909--11}, timestamp = {2011-03-11T10:06:21.000+0100}, title = {Equivalence of ceftriaxone and rifampicin in eliminating nasopharyngeal carriage of serogroup B Neisseria meningitidis}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10837450}, volume = 45, year = 2000 }